Orchestra BioMed Holdings, Inc.
US ˙ NasdaqGM ˙ US68572M1062

SecurityOBIO / Orchestra BioMed Holdings, Inc.
InstitutionState Street Corp
Latest Disclosed Ownership169,410 shares
Latest Disclosed Value $ 719,993
State Street Corp reports 6.53% increase in ownership of OBIO / Orchestra BioMed Holdings, Inc.

On May 15, 2026 - State Street Corp filed a 13F-HR form disclosing ownership of 169,410 shares of Orchestra BioMed Holdings, Inc. (US:OBIO) valued at $719,992 USD as of March 31, 2026. The entity filed a previous 13F-HR on February 13, 2026 disclosing 159,033 shares of Orchestra BioMed Holdings, Inc.. This represents a change in shares of 6.53% during the quarter. The current value of the position is $675,946 USD.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date
Effective
Date
Form Security Class ID Avg Price
Paid (Est)
Reported
Shares
ΔShares ΔShares
(%)
Reported
Value
(x1000)
ΔValue
(%)
Alloc
(%)
ΔAlloc ΔAlloc (%) Cost Basis
(x1000)
Unrealized
Gain/Loss
(x1000)
2026-05-15 2026-03-31 13F ORCHESTRA BIOMED HLDGS COM 68572M106 169,410 10,377 6.53 720 9.10 0.0000
2026-02-13 2025-12-31 13F ORCHESTRA BIOMED HLDGS COM 68572M106 159,033 58,300 57.88 660 164.66 0.0000
2025-11-14 2025-09-30 13F ORCHESTRA BIOMED HLDGS COM 68572M106 100,733 -29,400 -22.59 250 -28.45 0.0000
2025-08-14 2025-06-30 13F ORCHESTRA BIOMED HLDGS COM 68572M106 130,133 -343,586 -72.53 349 -82.83 0.0000
2025-05-15 2025-03-31 13F ORCHESTRA BIOMED HLDGS COM 68572M106 473,719 26,007 5.81 2,028 13.24 0.0001
2025-02-14 2024-12-31 13F ORCHESTRA BIOMED HLDGS COM 68572M106 447,712 18,099 4.21 1,791 -18.93 0.0001
2024-11-14 2024-09-30 13F ORCHESTRA BIOMED HLDGS COM 68572M106 429,613 47,308 12.37 2,208 -29.12 0.0001
2024-08-14 2024-06-30 13F ORCHESTRA BIOMED HLDGS COM 68572M106 382,305 127,358 49.95 3,116 131.94 0.0001
2024-05-15 2024-03-31 13F ORCHESTRA BIOMED HLDGS COM 68572M106 254,947 -30,963 -10.83 1,344 -48.54 0.0001
2024-02-14 2023-12-31 13F ORCHESTRA BIOMED HLDGS COM 68572M106 285,910 106,029 58.94 2,610 66.45 0.0001
2023-11-14 2023-09-30 13F ORCHESTRA BIOMED HLDGS COM 68572M106 179,881 38,044 26.82 1,569 58.06 0.0001
2023-08-14 2023-06-30 13F ORCHESTRA BIOMED HLDGS COM 68572M106 141,837 107,651 314.90 993 48.28 0.0001
2023-05-15 2023-03-31 13F ORCHESTRA BIOMED HLDGS COM 68572M106 34,186 34,186 669 0.0000
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.