Axsome Therapeutics, Inc.
US ˙ NasdaqGM ˙ US05464T1043

SecurityAXSM / Axsome Therapeutics, Inc.
InstitutionState Street Corp
Latest Disclosed Ownership986,809 shares
Latest Disclosed Value $ 166,790,457
State Street Corp reports 2.99% increase in ownership of AXSM / Axsome Therapeutics, Inc.

On May 15, 2026 - State Street Corp filed a 13F-HR form disclosing ownership of 986,809 shares of Axsome Therapeutics, Inc. (US:AXSM) valued at $166,790,457 USD as of March 31, 2026. The entity filed a previous 13F-HR on February 13, 2026 disclosing 958,150 shares of Axsome Therapeutics, Inc.. This represents a change in shares of 2.99% during the quarter. The current value of the position is $228,426,547 USD.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-05-15 2026-03-31 13F AXSOME THERAPEUTICS COM 05464T104 986,809 28,659 2.99 166,790 -4.69 0.0058
2026-02-13 2025-12-31 13F AXSOME THERAPEUTICS COM 05464T104 958,150 15,190 1.61 174,997 52.81 0.0059
2025-11-14 2025-09-30 13F AXSOME THERAPEUTICS COM 05464T104 942,960 -15,543 -1.62 114,522 14.46 0.0040
2025-08-14 2025-06-30 13F AXSOME THERAPEUTICS COM 05464T104 958,503 52,483 5.79 100,058 -5.31 0.0038
2025-05-15 2025-03-31 13F AXSOME THERAPEUTICS COM 05464T104 906,020 -41,231 -4.35 105,669 31.85 0.0044
2025-02-14 2024-12-31 13F AXSOME THERAPEUTICS COM 05464T104 947,251 30,443 3.32 80,147 -2.73 0.0032
2024-11-14 2024-09-30 13F AXSOME THERAPEUTICS COM 05464T104 916,808 -21,695 -2.31 82,394 9.06 0.0034
2024-08-14 2024-06-30 13F AXSOME THERAPEUTICS COM 05464T104 938,503 -213 -0.02 75,549 0.85 0.0033
2024-05-15 2024-03-31 13F AXSOME THERAPEUTICS COM 05464T104 938,716 14,526 1.57 74,910 1.84 0.0033
2024-02-14 2023-12-31 13F AXSOME THERAPEUTICS COM 05464T104 924,190 56,543 6.52 73,556 21.30 0.0036
2023-11-14 2023-09-30 13F AXSOME THERAPEUTICS COM 05464T104 867,647 42,458 5.15 60,640 2.26 0.0034
2023-08-14 2023-06-30 13F AXSOME THERAPEUTICS COM 05464T104 825,189 29,144 3.66 59,298 20.77 0.0031
2023-05-15 2023-03-31 13F AXSOME THERAPEUTICS COM 05464T104 796,045 39,175 5.18 49,100 -15.89 0.0028
2023-05-15 2022-12-31 13F/A-99 AXSOME THERAPEUTICS COM 05464T104 756,870 45,538 6.40 58,377 83.92 0.0034
2023-05-15 2022-12-31 13F AXSOME THERAPEUTICS COM 05464T104 756,870 45,538 58,377 0.0034
2022-11-15 2022-09-30 13F AXSOME THERAPEUTICS COM 05464T104 711,332 -141,651 -16.61 31,740 -2.84 0.0020
2022-08-15 2022-06-30 13F AXSOME THERAPEUTICS COM 05464T104 852,983 153,977 22.03 32,669 12.92 0.0020
2022-05-16 2022-03-31 13F AXSOME THERAPEUTICS COM 05464T104 699,006 -46,901 -6.29 28,932 2.67 0.0014
2022-02-14 2021-12-31 13F AXSOME THERAPEUTICS COM 05464T104 745,907 -39,666 -5.05 28,180 8.84 0.0013
2021-11-15 2021-09-30 13F AXSOME THERAPEUTICS COM 05464T104 785,573 145,816 22.79 25,892 -40.01 0.0014
2021-08-16 2021-06-30 13F AXSOME THERAPEUTICS COM 05464T104 639,757 10,589 1.68 43,158 21.15 0.0023
2021-07-09 2021-03-31 13F/A-1 AXSOME THERAPEUTICS COM 05464T104 629,168 -14,449 -2.24 35,623 -32.06 0.0020
2021-05-17 2021-03-31 13F AXSOME THERAPEUTICS COM 05464T104 629,168 -14,449 35,623 0.0020
2021-02-16 2020-12-31 13F AXSOME THERAPEUTICS COM 05464T104 643,617 -10,317 -1.58 52,435 12.54 0.0032
2020-11-10 2020-09-30 13F AXSOME THERAPEUTICS COM 05464T104 653,934 -66,792 -9.27 46,593 -21.43 0.0032
2020-08-14 2020-06-30 13F AXSOME THERAPEUTICS COM 05464T104 720,726 59,411 8.98 59,301 52.43 0.0043
2020-06-19 2020-03-31 13F/A-1 AXSOME THERAPEUTICS COM 05464T104 661,315 31,639 5.02 38,905 -40.22 0.0034
2020-05-11 2020-03-31 13F AXSOME THERAPEUTICS COM 05464T104 661,315 31,639 38,905 3,416.6424
2020-02-06 2019-12-31 13F AXSOME THERAPEUTICS COM 05464T104 629,676 -100,006 -13.71 65,083 340.67 0.0045
2019-11-14 2019-09-30 13F AXSOME THERAPEUTICS COM 05464T104 729,682 78,209 12.00 14,769 -11.96 0.0011
2019-08-14 2019-06-30 13F AXSOME THERAPEUTICS COM 05464T104 651,473 637,773 4,655.28 16,775 8,502.56 0.0013
2019-05-15 2019-03-31 13F AXSOME THERAPEUTICS COM 05464T104 13,700 13,700 195 0.0000
2017-08-14 2017-06-30 13F AXSOME THERAPEUTICS Common equity shares 05464T104 0 -138,188 -100.00 0 -100.00
2017-05-15 2017-03-31 13F AXSOME THERAPEUTICS Common equity shares 05464T104 138,188 3,500 2.60 540 -40.53 0.0000
2017-02-09 2016-12-31 13F AXSOME THERAPEUTICS Common equity shares 05464T104 134,688 8,466 6.71 908 -8.84 0.0001
2017-01-13 2016-09-30 13F/A-1 AXSOME THERAPEUTICS Common equity shares 05464T104 126,222 12,731 11.22 996 16.36 0.0001
2016-11-14 2016-09-30 13F AXSOME THERAPEUTICS Common equity shares 05464T104 126,222 996
2016-08-12 2016-06-30 13F AXSOME THERAPEUTICS Common equity shares 05464T104 113,491 113,491 856 0.0001
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.