Ionis Pharmaceuticals, Inc.
MX ˙ BMV ˙ US4622221004
SecurityMX:IONS / Ionis Pharmaceuticals, Inc.
InstitutionSector Gamma As
Latest Disclosed Ownership169,468 shares
Latest Disclosed Value $ 12,725,352
Sector Gamma As reports 8.38% decrease in ownership of IONS / Ionis Pharmaceuticals, Inc.

On May 7, 2026 - Sector Gamma As filed a 13F-HR form disclosing ownership of 169,468 shares of Ionis Pharmaceuticals, Inc. (MX:IONS) valued at $12,725,352 USD as of March 31, 2026. The entity filed a previous 13F-HR on February 12, 2026 disclosing 184,977 shares of Ionis Pharmaceuticals, Inc.. This represents a change in shares of -8.38% during the quarter.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-05-07 2026-03-31 13F IONIS PHARMACEUTICALS COM 462222100 169,468 -15,509 -8.38 12,725 -13.04 3.0049
2026-02-12 2025-12-31 13F IONIS PHARMACEUTICALS COM 462222100 184,977 -85,986 -31.73 14,634 -17.45 3.3355
2025-10-31 2025-09-30 13F IONIS PHARMACEUTICALS COM 462222100 270,963 -14,879 -5.21 17,726 56.96 4.3951
2025-07-31 2025-06-30 13F IONIS PHARMACEUTICALS COM 462222100 285,842 0 0.00 11,294 30.96 3.6914
2025-05-13 2025-03-31 13F IONIS PHARMACEUTICALS COM 462222100 285,842 50,000 21.20 8,624 4.58 2.7623
2025-02-11 2024-12-31 13F IONIS PHARMACEUTICALS COM 462222100 235,842 25,000 11.86 8,245 -2.38 2.8346
2024-11-13 2024-09-30 13F IONIS PHARMACEUTICALS COM 462222100 210,842 40,842 24.02 8,446 4.25 2.5627
2024-08-09 2024-06-30 13F IONIS PHARMACEUTICALS COM 462222100 170,000 -5,507 -3.14 8,102 6.49 3.0268
2024-05-08 2024-03-31 13F IONIS PHARMACEUTICALS COM 462222100 175,507 30,495 21.03 7,608 3.71 2.1444
2024-02-05 2023-12-31 13F IONIS PHARMACEUTICALS COM 462222100 145,012 -20,604 -12.44 7,336 -2.34 1.7801
2023-11-06 2023-09-30 13F IONIS PHARMACEUTICALS COM 462222100 165,616 5,215 3.25 7,512 14.15 1.9200
2023-08-09 2023-06-30 13F IONIS PHARMACEUTICALS COM 462222100 160,401 13,960 9.53 6,581 25.76 1.4725
2023-05-12 2023-03-31 13F IONIS PHARMACEUTICALS COM 462222100 146,441 5,068 3.58 5,234 -1.99 1.2688
2023-02-08 2022-12-31 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 141,373 -22,850 -13.91 5,340 -26.50 1.2208
2023-02-07 2022-12-31 13F IONIS PHARMACEUTICALS COM 462222100 141,373 -22,850 5 1.2208
2022-11-09 2022-09-30 13F IONIS PHARMACEUTICALS COM 462222100 164,223 -1,216 -0.74 7,264 18.60 1.8720
2022-08-05 2022-06-30 13F IONIS PHARMACEUTICALS COM 462222100 165,439 -23,000 -12.21 6,125 -12.25 1.3704
2022-05-06 2022-03-31 13F IONIS PHARMACEUTICALS COM 462222100 188,439 -21,098 -10.07 6,980 9.47 1.5167
2022-02-08 2021-12-31 13F IONIS PHARMACEUTICALS COM 462222100 209,537 -54,333 -20.59 6,376 -27.95 1.4988
2021-10-29 2021-09-30 13F IONIS PHARMACEUTICALS COM 462222100 263,870 382 0.14 8,850 -15.80 1.7654
2021-08-04 2021-06-30 13F IONIS PHARMACEUTICALS COM 462222100 263,488 -190,662 -41.98 10,511 -48.52 1.8616
2021-05-10 2021-03-31 13F IONIS PHARMACEUTICALS COM 462222100 454,150 133,158 41.48 20,419 12.51 3.7398
2021-02-10 2020-12-31 13F IONIS PHARMACEUTICALS COM 462222100 320,992 84,650 35.82 18,149 61.84 3.4538
2020-11-09 2020-09-30 13F IONIS PHARMACEUTICALS COM 462222100 236,342 46,361 24.40 11,214 0.12 2.5524
2020-08-07 2020-06-30 13F IONIS PHARMACEUTICALS COM 462222100 189,981 -85,500 -31.04 11,201 -14.00 2.3122
2020-05-11 2020-03-31 13F IONIS PHARMACEUTICALS COM 462222100 275,481 57,846 26.58 13,025 -0.93 2.7771
2020-02-12 2019-12-31 13F IONIS PHARMACEUTICALS COM 462222100 217,635 86,121 65.48 13,147 66.86 2.1056
2019-11-05 2019-09-30 13F IONIS PHARMACEUTICALS COM 462222100 131,514 0 0.00 7,879 -6.78 1.3313
2019-07-31 2019-06-30 13F IONIS PHARMACEUTICALS COM 462222100 131,514 -102,200 -43.73 8,452 -55.45 1.3586
2019-05-13 2019-03-31 13F IONIS PHARMACEUTICALS COM 462222100 233,714 -145,707 -38.40 18,971 -7.51 3.0424
2019-02-12 2018-12-31 13F IONIS PHARMACEUTICALS COM 462222100 379,421 176,987 87.43 20,512 96.44 3.4489
2018-11-15 2018-09-30 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 202,434 -100,806 -33.24 10,442 -17.36 1.6372
2018-11-08 2018-09-30 13F IONIS PHARMACEUTICALS COM 462222100 113,910 -189,330 5,875
2018-08-02 2018-06-30 13F IONIS PHARMACEUTICALS COM 462222100 303,240 29,740 10.87 12,636 4.81 2.1000
2018-05-09 2018-03-31 13F IONIS PHARMACEUTICALS COM 462222100 273,500 211,400 340.42 12,056 285.92 2.1728
2018-02-12 2017-12-31 13F IONIS PHARMACEUTICALS COM 462222100 62,100 62,100 3,124 0.5251
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.