Ionis Pharmaceuticals, Inc.
MX ˙ BMV ˙ US4622221004
SecurityMX:IONS / Ionis Pharmaceuticals, Inc.
InstitutionNatixis Advisors, L.p.
Latest Disclosed Ownership23,721 shares
Latest Disclosed Value $ 1,781
Natixis Advisors, L.p. reports 8.36% increase in ownership of IONS / Ionis Pharmaceuticals, Inc.

On May 13, 2026 - Natixis Advisors, L.p. filed a 13F-HR form disclosing ownership of 23,721 shares of Ionis Pharmaceuticals, Inc. (MX:IONS) valued at $1,781 USD as of March 31, 2026. The entity filed a previous 13F-HR on February 10, 2026 disclosing 21,891 shares of Ionis Pharmaceuticals, Inc.. This represents a change in shares of 8.36% during the quarter.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-05-13 2026-03-31 13F IONIS PHARMACEUTICALS COM 462222100 23,721 1,830 8.36 2 0.00 0.0025
2026-02-10 2025-12-31 13F IONIS PHARMACEUTICALS COM 462222100 21,891 21,891 2 0.0025
2025-05-08 2025-03-31 13F IONIS PHARMACEUTICALS COM 462222100 0 -14,313 -100.00 0 0.0000
2025-02-10 2024-12-31 13F IONIS PHARMACEUTICALS COM 462222100 14,313 -6,767 -32.10 0 0.0009
2024-11-06 2024-09-30 13F IONIS PHARMACEUTICALS COM 462222100 21,080 -2,324 -9.93 1 -100.00 0.0016
2024-08-01 2024-06-30 13F IONIS PHARMACEUTICALS COM 462222100 23,404 376 1.63 1 0.0024
2024-04-25 2024-03-31 13F IONIS PHARMACEUTICALS COM 462222100 23,028 5,715 33.01 1 0.0023
2024-02-06 2023-12-31 13F IONIS PHARMACEUTICALS COM 462222100 17,313 1,394 8.76 1 0.0023
2023-11-13 2023-09-30 13F IONIS PHARMACEUTICAL COM 462222100 15,919 -279 -1.72 1 0.0022
2023-08-15 2023-06-30 13F IONIS PHARMACEUTICALS COM 462222100 16,198 122 0.76 1 0.0021
2023-05-11 2023-03-31 13F IONIS PHARMACEUTICALS COM 462222100 16,076 -127 -0.78 1 0.0020
2023-01-27 2022-12-31 13F IONIS PHARMACEUTICALS COM 462222100 16,203 385 2.43 1 -100.00 0.0023
2022-11-14 2022-09-30 13F IONIS PHARMACEUTICALS COM 462222100 15,818 -12 -0.08 700 19.45 0.0030
2022-08-12 2022-06-30 13F IONIS PHARMACEUTICALS COM 462222100 15,830 -31 -0.20 586 -0.17 0.0026
2022-05-12 2022-03-31 13F IONIS PHARMACEUTICALS COM 462222100 15,861 -34 -0.21 587 21.28 0.0022
2022-02-08 2021-12-31 13F IONIS PHARMACEUTICALS COM 462222100 15,895 -1,833 -10.34 484 -18.66 0.0018
2021-11-15 2021-09-30 13F IONIS PHARMACEUTICALS COM 462222100 17,728 -1,136 -6.02 595 -20.88 0.0024
2021-08-12 2021-06-30 13F IONIS PHARMACEUTICALS COM 462222100 18,864 -1,740 -8.44 752 -18.79 0.0035
2021-05-05 2021-03-31 13F IONIS PHARMACEUTICALS COM 462222100 20,604 -4,819 -18.96 926 -35.56 0.0048
2021-02-12 2020-12-31 13F IONIS PHARMACEUTICALS COM 462222100 25,423 -138,898 -84.53 1,437 -81.57 0.0083
2020-11-12 2020-09-30 13F IONIS PHARMACEUTICALS COM 462222100 164,321 -3,185 -1.90 7,797 -21.05 0.0491
2020-08-11 2020-06-30 13F IONIS PHARMACEUTICALS COM 462222100 167,506 27,799 19.90 9,876 49.52 0.0655
2020-04-27 2020-03-31 13F IONIS PHARMACEUTICALS COM 462222100 139,707 825 0.59 6,605 -21.28 0.0538
2020-02-10 2019-12-31 13F IONIS PHARMACEUTICALS COM 462222100 138,882 15,496 12.56 8,390 13.50 0.0592
2019-11-12 2019-09-30 13F IONIS PHARMS COM 462222100 123,386 2,182 1.80 7,392 -5.11 0.0587
2019-08-12 2019-06-30 13F IONIS PHARMS COM 462222100 121,204 14,681 13.78 7,790 -9.90 0.0636
2019-05-15 2019-03-31 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 106,523 -4,065 -3.68 8,646 44.63 0.0757
2019-05-15 2019-03-31 13F IONIS PHARMACEUTICALS COM 462222100 106,523 -4,065 8,646
2019-02-13 2018-12-31 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 110,588 -1,469 -1.31 5,978 3.44 0.0590
2019-02-13 2018-12-31 13F IONIS PHARMACEUTICALS COM 462222100 110,588 -1,469 5,978
2018-11-13 2018-09-30 13F IONIS PHARMACEUTICALS COM 462222100 112,057 -11,794 -9.52 5,779 12.00 0.0509
2018-08-14 2018-06-30 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 123,851 -8,045 -6.10 5,160 -11.25 0.0493
2018-08-14 2018-06-30 13F IONIS PHARMACEUTICALS COM 462222100 123,851 5,160
2018-05-10 2018-03-31 13F IONIS PHARMACEUTICALS COM 462222100 131,896 4,300 3.37 5,814 -9.41 0.0574
2018-02-14 2017-12-31 13F IONIS PHARMACEUTICALS COM 462222100 127,596 822 0.65 6,418 -0.14 0.0654
2017-11-14 2017-09-30 13F IONIS PHARMACEUTICALS COM 462222100 126,774 -3,241 -2.49 6,427 -2.83 0.0679
2017-07-27 2017-06-30 13F IONIS PHARMACEUTICALS COM 462222100 130,015 1,636 1.27 6,614 28.15 0.0716
2017-05-12 2017-03-31 13F IONIS PHARMACEUTICALS COM 462222100 128,379 -4,621 -3.47 5,161 -18.86 0.0572
2017-02-07 2016-12-31 13F IONIS PHARMACEUTICALS COM 462222100 133,000 41,745 45.75 6,361 90.22 0.0765
2016-11-04 2016-09-30 13F IONIS PHARMACEUTICALS COM 462222100 91,255 -6,230 -6.39 3,344 47.31 0.0433
2016-08-01 2016-06-30 13F IONIS PHARMACEUTICALS COM 462222100 97,485 17,009 21.14 2,270 -30.35 0.0314
2016-05-06 2016-03-31 13F IONIS PHARMACEUTICALS COM 462222100 80,476 31,206 63.34 3,259 6.82 0.0488
2016-02-12 2015-12-31 13F IONIS PHARMACEUTICALS COM 462222100 49,270 3,295 7.17 3,051 64.21 0.0500
2015-11-12 2015-09-30 13F ISIS PHARMACEUTICALS COM 464330109 45,975 2,095 4.77 1,858 -26.42 0.0322
2015-08-14 2015-06-30 13F ISIS PHARMACEUTICALS COM 464330109 43,880 653 1.51 2,525 -8.25 0.0429
2015-05-15 2015-03-31 13F ISIS PHARMACEUTICALS COM 464330109 43,227 -1,504 -3.36 2,752 -0.36 0.0483
2015-02-05 2014-12-31 13F ISIS PHARMACEUTICALS COM 464330109 44,731 4,180 10.31 2,762 75.37 0.0517
2014-11-03 2014-09-30 13F ISIS PHARMACEUTICALS COM 464330109 40,551 5,444 15.51 1,575 30.27 0.0316
2014-08-13 2014-06-30 13F ISIS PHARMACEUTICALS COM 464330109 35,107 4,984 16.55 1,209 -7.14 0.0173
2014-05-13 2014-03-31 13F ISIS PHARMACEUTICALS COM 464330109 30,123 -2,848 -8.64 1,302 -0.91 0.0200
2014-02-12 2013-12-31 13F ISIS PHARMACEUTICALS COM 464330109 32,971 -1,475 -4.28 1,314 1.62 0.0215
2013-10-30 2013-09-30 13F ISIS PHARMACEUTICALS COM 464330109 34,446 -8,200 -19.23 1,293 12.83 0.0238
2013-07-19 2013-06-30 13F ISIS PHARMACEUTICALS COM 464330109 42,646 42,646 1,146 0.0228
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.