Ionis Pharmaceuticals, Inc.
MX ˙ BMV ˙ US4622221004
SecurityMX:IONS / Ionis Pharmaceuticals, Inc.
InstitutionComerica Bank
Latest Disclosed Ownership3,997 shares
Latest Disclosed Value $ 316,242
Comerica Bank reports 82.76% increase in ownership of IONS / Ionis Pharmaceuticals, Inc.

On January 29, 2026 - Comerica Bank filed a 13F-HR form disclosing ownership of 3,997 shares of Ionis Pharmaceuticals, Inc. (MX:IONS) valued at $316,242 USD as of December 31, 2025. The entity filed a previous 13F-HR on November 14, 2025 disclosing 2,187 shares of Ionis Pharmaceuticals, Inc.. This represents a change in shares of 82.76% during the quarter.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-01-29 2025-12-31 13F IONIS PHARMACEUTICALS COM 462222100 3,997 1,810 82.76 316 120.98 0.0013
2025-11-14 2025-09-30 13F IONIS PHARMACEUTICALS COM 462222100 2,187 570 35.25 143 126.98 0.0005
2025-08-14 2025-06-30 13F IONIS PHARMACEUTICALS COM 462222100 1,617 297 22.50 64 61.54 0.0002
2025-05-14 2025-03-31 13F IONIS PHARMACEUTICALS COM 462222100 1,320 -6,073 -82.15 40 -84.88 0.0002
2025-02-14 2024-12-31 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 7,393 -222 -2.92 258 -15.41 0.0010
2025-02-14 2024-12-31 13F IONIS PHARMACEUTICALS COM 462222100 7,393 -222 258 0.0009
2024-11-14 2024-09-30 13F IONIS PHARMACEUTICALS COM 462222100 7,615 -13,809 -64.46 305 -70.13 0.0012
2024-08-15 2024-06-30 13F IONIS PHARMACEUTICALS COMMON 462222100 21,424 -18,067 -45.75 1,021 -40.33 0.0042
2024-05-16 2024-03-31 13F IONIS PHARMACEUTICALS COMMON 462222100 39,491 -123 -0.31 1,712 -14.58 0.0074
2024-02-14 2023-12-31 13F IONIS PHARMACEUTICALS COMMON 462222100 39,614 -334 -0.84 2,004 10.54 0.0092
2023-11-21 2023-09-30 13F IONIS PHARMACEUTICALS COMMON 462222100 39,948 39,410 7,325.28 1,812 0.0094
2023-08-22 2023-06-30 13F IONIS PHARMACEUTICALS EQU 462222100 538 -10,984 -95.33 0 0.0006
2023-01-26 2022-12-31 13F IONIS PHARMACEUTICALS COM 462222100 11,522 -17 -0.15 0 -100.00 0.0036
2022-10-28 2022-09-30 13F IONIS PHARMACEUTICALS COM 462222100 11,539 -145 -1.24 516 12.42 0.0044
2022-08-02 2022-06-30 13F IONIS PHARMACEUTICALS COM 462222100 11,684 -71 -0.60 459 -9.29 0.0038
2022-04-27 2022-03-31 13F IONIS PHARMACEUTICALS COM 462222100 11,755 0 0.00 506 36.76 0.0037
2022-02-18 2021-12-31 13F IONIS PHARMACEUTICALS COM 462222100 11,755 -75 -0.63 370 2.78 0.0027
2021-11-22 2021-09-30 13F IONIS PHARMACEUTICALS COM 462222100 11,830 -3,761 -24.12 360 -38.98 0.0022
2021-08-26 2021-06-30 13F IONIS PHARMACEUTICALS COM 462222100 15,591 -105 -0.67 590 -11.94 0.0035
2021-04-28 2021-03-31 13F IONIS PHARMACEUTICALS COM 462222100 15,696 -352 -2.19 670 -32.39 0.0040
2021-01-28 2020-12-31 13F IONIS PHARMACEUTICALS COM 462222100 16,048 -466 -2.82 991 26.73 0.0063
2020-10-30 2020-09-30 13F IONIS PHARMACEUTICALS COM 462222100 16,514 -62 -0.37 782 -22.27 0.0057
2020-07-31 2020-06-30 13F IONIS PHARMACEUTICALS COM 462222100 16,576 297 1.82 1,006 6.34 0.0078
2020-05-01 2020-03-31 13F IONIS PHARMACEUTICALS COM 462222100 16,279 400 2.52 946 0.00 0.0087
2020-02-07 2019-12-31 13F IONIS PHARMACEUTICALS COM 462222100 15,879 205 1.31 946 12.09 0.0072
2019-10-31 2019-09-30 13F IONIS PHARMACEUTICALS COM 462222100 15,674 84 0.54 844 -19.70 0.0067
2019-08-02 2019-06-30 13F IONIS PHARMACEUTICALS COM 462222100 15,590 170 1.10 1,051 -20.38 0.0084
2019-05-02 2019-03-31 13F IONIS PHARMACEUTICALS COM 462222100 15,420 -4 -0.03 1,320 56.77 0.0107
2019-02-06 2018-12-31 13F IONIS PHARMACEUTICALS COM 462222100 15,424 -368 -2.33 842 9.21 0.0072
2018-11-01 2018-09-30 13F IONIS PHARMACEUTICALS COM 462222100 15,792 -164 -1.03 771 9.52 0.0062
2018-08-01 2018-06-30 13F IONIS PHARMACEUTICALS COM 462222100 15,956 8 0.05 704 -3.69 0.0049
2018-05-01 2018-03-31 13F IONIS PHARMACEUTICALS COM 462222100 15,948 -121 -0.75 731 -14.70 0.0052
2018-02-02 2017-12-31 13F IONIS PHARMACEUTICALS COM 462222100 16,069 -112 -0.69 857 -9.22 0.0057
2017-11-06 2017-09-30 13F IONIS PHARMACEUTICALS COM 462222100 16,181 10 0.06 944 -1.97 0.0068
2017-08-03 2017-06-30 13F IONIS PHARMACEUTICALS COM 462222100 16,171 -373 -2.25 963 22.36 0.0072
2017-05-03 2017-03-31 13F IONIS PHARMACEUTICALS COM 462222100 16,544 39 0.24 787 -0.88 0.0060
2017-02-08 2016-12-31 13F IONIS PHARMACEUTICALS COM 462222100 16,505 4,477 37.22 794 81.69 0.0063
2016-08-11 2016-06-30 13F IONIS PHARMACEUTICALS COM 462222100 12,028 -165 -1.35 437 -15.64 0.0038
2016-05-11 2016-03-31 13F IONIS PHARMACEUTICALS COM 462222100 12,193 267 2.24 518 -23.60 0.0046
2016-02-05 2015-12-31 13F IONIS PHARMACEUTICALS COM 462222100 11,926 -490 -3.95 678 35.06 0.0067
2015-11-12 2015-09-30 13F ISIS PHARMACEUTICALS COM 464330109 12,416 -11,996 -49.14 502 -64.25 0.0048
2015-08-13 2015-06-30 13F ISIS PHARMACEUTICALS COM 464330109 24,412 12,187 99.69 1,404 80.46 0.0060
2015-05-15 2015-03-31 13F ISIS PHARMACEUTICALS COM 464330109 12,225 -12,411 -50.38 778 -48.88 0.0066
2015-02-13 2014-12-31 13F ISIS PHARMACEUTICALS COM 464330109 24,636 12,447 102.12 1,522 221.78 0.0066
2014-10-21 2014-09-30 13F ISIS PHARMACEUTICALS COM 464330109 12,189 -1,017 -7.70 473 3.96 0.0042
2014-08-12 2014-06-30 13F ISIS PHARMACEUTICALS COM 464330109 13,206 -9,010 -40.56 455 -52.60 0.0039
2014-05-15 2014-03-31 13F ISIS PHARMACEUTICALS COM 464330109 22,216 413 1.89 960 10.60 0.0074
2014-02-11 2013-12-31 13F ISIS PHARMACEUTICALS COM 464330109 21,803 -31,696 -59.25 868 -56.77 0.0067
2013-11-12 2013-09-30 13F ISIS PHARMACEUTICALS COM 464330109 53,499 -5,042 -8.61 2,008 27.74 0.0140
2013-08-13 2013-06-30 13F/A-1 ISIS PHARMACEUTICALS COM 464330109 58,541 58,541 1,572 0.0128
2013-08-08 2013-06-30 13F ISIS PHARMACEUTICALS COM 464330109 228,914 6,148
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.