Ionis Pharmaceuticals, Inc.
MX ˙ BMV ˙ US4622221004
SecurityMX:IONS / Ionis Pharmaceuticals, Inc.
InstitutionAmalgamated Bank
Latest Disclosed Ownership12,054 shares
Latest Disclosed Value $ 905
Amalgamated Bank reports 3.22% decrease in ownership of IONS / Ionis Pharmaceuticals, Inc.

On May 8, 2026 - Amalgamated Bank filed a 13F-HR form disclosing ownership of 12,054 shares of Ionis Pharmaceuticals, Inc. (MX:IONS) valued at $905 USD as of March 31, 2026. The entity filed a previous 13F-HR on February 5, 2026 disclosing 12,455 shares of Ionis Pharmaceuticals, Inc..

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-05-08 2026-03-31 13F IONIS PHARMACEUTICALS COM 462222100 12,054 -401 -3.22 1 0.0069
2026-02-05 2025-12-31 13F IONIS PHARMACEUTICALS COM 462222100 12,455 260 2.13 1 0.0071
2025-10-29 2025-09-30 13F IONIS PHARMACEUTICALS COM 462222100 12,195 669 5.80 1 0.0057
2025-08-04 2025-06-30 13F IONIS PHARMACEUTICALS COM 462222100 11,526 953 9.01 0 0.0035
2025-04-25 2025-03-31 13F IONIS PHARMACEUTICALS COM 462222100 10,573 281 2.73 0 0.0027
2025-02-04 2024-12-31 13F IONIS PHARMACEUTICALS COM 462222100 10,292 335 3.36 0 0.0030
2024-10-30 2024-09-30 13F IONIS PHARMACEUTICALS COM 462222100 9,957 300 3.11 0 0.0033
2024-08-12 2024-06-30 13F IONIS PHARMACEUTICALS COM 462222100 9,657 454 4.93 0 0.0039
2024-04-23 2024-03-31 13F IONIS PHARMACEUTICALS COM 462222100 9,203 -19,792 -68.26 0 -100.00 0.0034
2024-02-06 2023-12-31 13F IONIS PHARMACEUTICALS COM 462222100 28,995 -91 -0.31 1 0.00 0.0117
2023-11-08 2023-09-30 13F IONIS PHARMACEUTICALS COM 462222100 29,086 -373 -1.27 1 0.00 0.0112
2023-08-11 2023-06-30 13F IONIS PHARMACEUTICALS COM 462222100 29,459 351 1.21 1 0.00 0.0098
2023-05-02 2023-03-31 13F IONIS PHARMACEUTICALS COM 462222100 29,108 -2,987 -9.31 1 0.00 0.0089
2023-02-10 2022-12-31 13F IONIS PHARMACEUTICALS COM 462222100 32,095 503 1.59 1 -99.93 0.0108
2022-11-09 2022-09-30 13F IONIS PHARMACEUTICALS COM 462222100 31,592 -1,731 -5.19 1,397 13.21 0.0135
2022-08-15 2022-06-30 13F IONIS PHARMACEUTICALS COM 462222100 33,323 1,389 4.35 1,234 4.31 0.0115
2022-08-25 2022-03-31 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 31,934 2,610 8.90 1,183 32.62 0.0092
2022-06-30 2022-03-31 13F IONIS PHARMACEUTICALS COM 462222100 31,934 2,610 1,183 0.0094
2022-02-15 2021-12-31 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 29,324 3,923 15.44 892 4.69 0.0066
2022-02-15 2021-12-31 13F IONIS PHARMACEUTICALS COM 462222100 29,324 3,923 892 0.0066
2021-10-29 2021-09-30 13F IONIS PHARMACEUTICALS COM 462222100 25,401 -1,532 -5.69 852 -20.67 0.0072
2021-08-16 2021-06-30 13F IONIS PHARMACEUTICALS COM 462222100 26,933 7,267 36.95 1,074 21.49 0.0086
2021-05-13 2021-03-31 13F IONIS PHARMACEUTICALS COM 462222100 19,666 -1,586 -7.46 884 -26.46 0.0331
2021-02-12 2020-12-31 13F IONIS PHARMACEUTICALS COM 462222100 21,252 -28 -0.13 1,202 19.01 0.0456
2020-10-30 2020-09-30 13F IONIS PHARMACEUTICALS COM 462222100 21,280 -319 -1.48 1,010 -20.66 0.0439
2020-08-10 2020-06-30 13F IONIS PHARMACEUTICALS COM 462222100 21,599 -12,106 -35.92 1,273 -20.14 0.0589
2020-05-13 2020-03-31 13F IONIS PHARMACEUTICALS COM 462222100 33,705 -931 -2.69 1,594 -23.80 0.0390
2020-02-13 2019-12-31 13F IONIS PHARMACEUTICALS COM 462222100 34,636 2,149 6.61 2,092 7.50 0.0385
2019-11-13 2019-09-30 13F IONIS PHARMACEUTICALS COM 462222100 32,487 4,195 14.83 1,946 7.04 0.0409
2019-08-14 2019-06-30 13F IONIS PHARMACEUTICALS COM 462222100 28,292 -108 -0.38 1,818 -21.13 0.0424
2019-05-15 2019-03-31 13F IONIS PHARMACEUTICALS COM 462222100 28,400 521 1.87 2,305 52.95 0.0559
2019-02-15 2018-12-31 13F IONIS PHARMACEUTICALS COM 462222100 27,879 10,762 62.87 1,507 70.67 0.0427
2018-11-14 2018-09-30 13F IONIS PHARMACEUTICALS COM 462222100 17,117 -12,049 -41.31 883 -27.33 0.0218
2018-07-18 2018-06-30 13F IONIS PHARMACEUTICALS COM 462222100 29,166 2,762 10.46 1,215 4.38 0.0297
2018-05-22 2018-03-31 13F IONIS PHARMACEUTICALS COM 462222100 26,404 1,702 6.89 1,164 -6.36 0.0309
2018-02-13 2017-12-31 13F IONIS PHARMACEUTICALS COM 462222100 24,702 1,350 5.78 1,243 4.98 0.0336
2017-11-09 2017-09-30 13F IONIS PHARMACEUTICALS COM 462222100 23,352 161 0.69 1,184 0.34 0.0369
2017-08-10 2017-06-30 13F IONIS PHARMACEUTICALS COM 462222100 23,191 5,612 31.92 1,180 66.90 0.0387
2017-05-12 2017-03-31 13F IONIS PHARMACEUTICALS COM 462222100 17,579 -3,880 -18.08 707 -31.09 0.0352
2017-02-14 2016-12-31 13F IONIS PHARMACEUTICALS COM 462222100 21,459 2,225 11.57 1,026 45.53 0.0464
2016-11-15 2016-09-30 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 19,234 2 0.01 705 2.17 0.0409
2016-08-16 2016-06-30 13F IONIS PHARMACEUTICALS COM 462222100 19,232 5,071 35.81 690 20.21 0.0399
2016-05-11 2016-03-31 13F IONIS PHARMACEUTICALS COM 462222100 14,161 1,108 8.49 574 -28.96 0.0559
2016-02-10 2015-12-31 13F IONIS PHARMACEUTICALS COM 462222100 13,053 -945 -6.75 808 42.76 0.0997
2015-11-04 2015-09-30 13F ISIS PHARMACEUTICALS COM 464330109 13,998 210 1.52 566 -28.63 0.0594
2015-07-10 2015-06-30 13F ISIS PHARMACEUTICALS COM 464330109 13,788 1,844 15.44 793 4.34 0.0779
2015-04-22 2015-03-31 13F ISIS PHARMACEUTICALS COM 464330109 11,944 11,944 0.00 760 0.0928
2015-01-29 2014-12-31 13F ISIS PHARMACEUTICALS COM 464330109 0 -11,467 -100.00 0 -100.00
2014-11-14 2014-09-30 13F ISIS PHARMACEUTICALS COM 464330109 11,467 -5 -0.04 445 12.66 0.0662
2014-08-11 2014-06-30 13F ISIS PHARMACEUTICALS COM 464330109 11,472 -68 -0.59 395 -20.84 0.0596
2014-05-12 2014-03-31 13F ISIS PHARMACEUTICALS INC COM COM 464330109 11,540 -105 -0.90 499 7.54 0.0860
2014-02-13 2013-12-31 13F ISIS PHARMACEUTICALS INC COM COM 464330109 11,645 11,645 464 0.0789
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.