BioCryst Pharmaceuticals, Inc.
MX ˙ BMV ˙ US09058V1035
SecurityMX:BCRX / BioCryst Pharmaceuticals, Inc.
InstitutionSei Investments Co
Latest Disclosed Ownership103,157 shares
Latest Disclosed Value $ 804,607
Sei Investments Co reports 71.52% decrease in ownership of BCRX / BioCryst Pharmaceuticals, Inc.

On February 13, 2026 - Sei Investments Co filed a 13F-HR form disclosing ownership of 103,157 shares of BioCryst Pharmaceuticals, Inc. (MX:BCRX) valued at $804,607 USD as of December 31, 2025. The entity filed a previous 13F-HR on November 13, 2025 disclosing 362,216 shares of BioCryst Pharmaceuticals, Inc.. This represents a change in shares of -71.52% during the quarter.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

Upgrade to unlock premium data and export to Excel .

Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-02-13 2025-12-31 13F BIOCRYST PHARMACEUTICALS COM 09058V103 103,157 -259,059 -71.52 805 -70.75 0.0008
2025-11-13 2025-09-30 13F BIOCRYST PHARMACEUTICALS COM 09058V103 362,216 138,973 62.25 2,749 37.45 0.0030
2025-08-14 2025-06-30 13F BIOCRYST PHARMACEUTICALS COM 09058V103 223,243 113,776 103.94 2,000 143.61 0.0023
2025-05-14 2025-03-31 13F/A-1 BIOCRYST PHARMACEUTICALS COM 09058V103 109,467 52,277 91.41 821 90.93 0.0011
2025-05-13 2025-03-31 13F BIOCRYST PHARMACEUTICALS COM 09058V103 44,419 -12,771 334 0.0004
2025-02-11 2024-12-31 13F BIOCRYST PHARMACEUTICALS COM 09058V103 57,190 1,537 2.76 430 1.90 0.0006
2024-11-12 2024-09-30 13F BIOCRYST PHARMACEUTICALS COM 09058V103 55,653 13,806 32.99 423 63.57 0.0005
2024-08-13 2024-06-30 13F BIOCRYST PHARMACEUTICALS COM 09058V103 41,847 -385 -0.91 259 20.56 0.0004
2024-05-07 2024-03-31 13F BIOCRYST PHARMACEUTICALS COM 09058V103 42,232 3,070 7.84 215 -8.55 0.0003
2024-02-14 2023-12-31 13F BIOCRYST PHARMACEUTICALS COM 09058V103 39,162 1,156 3.04 235 -13.01 0.0004
2023-11-14 2023-09-30 13F BIOCRYST PHARMACEUTICALS COM 09058V103 38,006 11,011 40.79 269 41.58 0.0005
2023-08-11 2023-06-30 13F BIOCRYST PHARMACEUTICALS COM 09058V103 26,995 -16,509 -37.95 190 -47.51 0.0003
2023-05-12 2023-03-31 13F BIOCRYST PHARMACEUTICALS COM 09058V103 43,504 -28,906 -39.92 363 -56.44 0.0007
2023-02-10 2022-12-31 13F BIOCRYST PHARMACEUTICALS COM 09058V103 72,410 46,227 176.55 831 151.82 0.0018
2022-11-14 2022-09-30 13F BIOCRYST PHARMACEUTICALS COM 09058V103 26,183 -3,233 -10.99 330 6.11 0.0007
2022-08-15 2022-06-30 13F BIOCRYST PHARMACEUTICALS COM 09058V103 29,416 -49,237 -62.60 311 -75.68 0.0007
2022-05-13 2022-03-31 13F BIOCRYST PHARMACEUTICALS COM 09058V103 78,653 42,925 120.14 1,279 158.38 0.0026
2022-02-14 2021-12-31 13F BIOCRYST PHARMACEUTICALS COM 09058V103 35,728 -44,405 -55.41 495 -56.99 0.0009
2021-11-12 2021-09-30 13F BIOCRYST PHARMACEUTICALS COM 09058V103 80,133 -38,604 -32.51 1,151 -38.68 0.0024
2021-08-06 2021-06-30 13F BIOCRYST PHARMACEUTICALS COM 09058V103 118,737 118,737 1,877 0.0042
2020-12-04 2020-09-30 13F/A-1 BIOCRYST PHARMACEUTICALS COM 09058V103 0 -94,898 -100.00 0 -100.00
2020-08-17 2020-06-30 13F/A-1 BIOCRYST PHARMACEUTICALS COM 09058V103 94,898 94,898 452 0.0014
2020-08-11 2020-06-30 13F BIOCRYST PHARMACEUTICALS COM 09058V103 94,898 94,898 452 1,226.0741
2019-08-14 2019-06-30 13F BIOCRYST PHARMACEUTICALS COM 09058V103 0 -59,358 -100.00 0 -100.00
2019-05-15 2019-03-31 13F BIOCRYST PHARMACEUTICALS COM 09058V103 59,358 -16,472 -21.72 483 -21.08 0.0016
2019-02-13 2018-12-31 13F BIOCRYST PHARMACEUTICALS COM 09058V103 75,830 75,830 27.75 612 26.71 0.0022
2018-11-08 2018-09-30 13F BIOCRYST PHARMACEUTICALS COM 09058V103 0 -588 -100.00 0 -100.00
2018-08-03 2018-06-30 13F BIOCRYST PHARMACEUTICALS COM 09058V103 588 0 0.00 4 33.33 0.0000
2018-05-11 2018-03-31 13F BIOCRYST PHARMACEUTICALS COM 09058V103 588 0 0.00 3 0.00 0.0000
2018-02-08 2017-12-31 13F BIOCRYST PHARMACEUTICALS COM 09058V103 588 0 0.00 3 0.00 0.0000
2017-11-06 2017-09-30 13F BIOCRYST PHARMACEUTICALS COM 09058V103 588 146 33.03 3 50.00 0.0000
2017-07-31 2017-06-30 13F BIOCRYST PHARMACEUTICALS COM 09058V103 442 0 0.00 2 -50.00 0.0000
2017-05-05 2017-03-31 13F BIOCRYST PHARMACEUTICALS COM 09058V103 442 0 0.00 4 33.33 0.0000
2017-02-02 2016-12-31 13F BIOCRYST PHARMACEUTICALS COM 09058V103 442 0 0.00 3 50.00 0.0000
2016-11-04 2016-09-30 13F BIOCRYST PHARMACEUTICALS COM 09058V103 442 0 0.00 2 100.00 0.0000
2016-08-11 2016-06-30 13F BIOCRYST PHARMACEUTICALS COM 09058V103 442 442 0.00 1 -50.00 0.0000
2016-05-10 2016-03-31 13F/A-1 BIOCRYST PHARMACEUTICALS COM 09058V103 0 0 0 0.0000
2016-02-03 2015-12-31 13F BIOCRYST PHARMACEUTICALS COM 09058V103 0 -27,734 -100.00 0 -100.00
2015-11-02 2015-09-30 13F/A-1 BIOCRYST PHARMACEUTICALS COM 09058V103 27,734 27,734 316 0.0029
2015-10-30 2015-09-30 13F BIOCRYST PHARMACEUTICALS COM 09058V103 27,734 317
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.