| Akcje insidera | 812 677 shares |
Wynik sentymentu insiderów
Ocena sentymentu insiderów pokazuje firmy, które są kupowane przez insiderów korporacyjnych.
Jest to wynik zaawansowanego, wieloczynnikowego modelu ilościowego, który identyfikuje spółki o najwyższym poziomie akumulacji informacji poufnych. Model rankingowy wykorzystuje kombinację liczby netto insiderów kupujących w ciągu ostatnich 90 dni, całkowitej liczby akcji kupionych jako procent akcji w obrocie oraz całkowitej liczby akcji posiadanych przez insiderów. Liczba ta waha się od 0 do 100, przy czym wyższe liczby wskazują na wyższy poziom akumulacji w porównaniu z innymi spółkami, a 50 to średnia.
Częstotliwość aktualizacji: codziennie
Ocena sentymentu kadry kierowniczej
Ocena sentymentu kadry kierowniczej pokazuje, że firmy są kupowane przez urzędników korporacyjnych.
Z definicji dyrektorzy korporacyjni to insiderzy korporacyjni, ale w przeciwieństwie do niektórych innych insiderów (10% akcjonariuszy i członków zarządu), dyrektorzy pracują dla firmy na co dzień i podczas handlu korzystają z własnych pieniędzy. (10% Akcjonariusze i członkowie zarządu często zarządzają funduszami zarządzających pieniędzmi innych osób). W związku z tym transakcje wykorzystujące informacje poufne dokonywane przez osoby z kadry kierowniczej mają znacznie większe znaczenie i powinny być odpowiednio traktowane.
Podobnie jak ocena sentymentu insiderów, ocena sentymentu kadry kierowniczej jest wynikiem zaawansowanego, wieloczynnikowego modelu ilościowego, który identyfikuje firmy o najwyższym poziomie akumulacji urzędników.
Częstotliwość aktualizacji: codziennie
Kluczowe wskaźniki insider
Ta karta pokazuje pozycję firmy według różnych wskaźników insider. Ranking według miary percentyla pokazuje, jak ta firma wypada na tle innych firm na rynkach amerykańskich. Wyższe rankingi wskazują na lepszą sytuację.
Na przykład ogólnie przyjmuje się, że kupowanie przez insiderów jest pozytywnym wskaźnikiem, zatem spółki z większą liczbą takich transakcji plasowałyby się wyżej niż spółki z mniejszą liczbą takich transakcji (lub nawet sprzedaży przez insiderów.
Liczba netto zakupów dokonanych przez insiderów (ranking)
N/A
Liczba netto zakupów dokonanych przez insiderów to łączna liczba insiderów kupujących pomniejszona o całkowitą liczbę insiderów sprzedających w ciągu ostatnich 90 dni. Tutaj pokazana jest miara percentyla (zakres od 0 do 100%).
Procent akcji kupowanych przez insiderów (ranking)
N/A
Procent akcji zakupionych przez insiderów to całkowita liczba akcji zakupionych przez insiderów pomniejszona o całkowitą liczbę akcji sprzedanych przez insiderów w ciągu ostatnich 90 dni, podzielona przez całkowitą liczbę akcji zakupionych przez insiderów i pomnożona przez 100.
Wykres handlu insider
Poniższy wykres przedstawia Pieris Pharmaceuticals, Inc. transakcji zrealizowanych przez insiderów. Insiderzy to członkowie kadry kierowniczej, dyrektorzy lub znaczący inwestorzy w spółce. Ogólnie rzecz biorąc, dokonywanie transakcji w ich firmach przez osoby posiadające dostęp do informacji poufnych w oparciu o istotne, niepubliczne informacje jest generalnie nielegalne. Nie oznacza to, że dokonywanie jakichkolwiek transakcji we własnych firmach jest nielegalne. Muszą jednak zgłaszać wszystkie transakcje do SEC za pośrednictwem formularza 4.
Lista insiderów i wskaźniki rentowności
Ta tabela przedstawia listę znanych insiderów i jest generowana automatycznie na podstawie zgłoszeń ujawnianych SEC. Oprócz nazwisk, najnowszego tytułu oraz oznaczenia dyrektora, członka kierownictwa lub 10% właściciela, podajemy najnowsze ujawnione pakiety akcji. Dodatkowo, jeśli to możliwe, udostępniamy historyczne wyniki handlowe danego insidera. Historyczne wyniki handlowe to średnia ważona wyników rzeczywistych transakcji zakupu na otwartym rynku dokonanych przez insiderów. Więcej informacji na temat sposobu obliczania tej wartości obejrzyj webinar na YouTube.
See our leaderboard of most profitable insider traders.
| Insider | Średni zysk (%) | Posiadane Akcje |
Podział korygujący |
|---|
Report errors via our new Insider Auditing Tool
Śledź historię zakupów insiderów — analiza zysków krótkoterminowych
W tej sekcji analizujemy rentowność każdego nieplanowanego zakupu od poufnych informacji na otwartym rynku dokonanego w PIRS / Pieris Pharmaceuticals, Inc.. Analiza ta pomaga zrozumieć, czy insider konsekwentnie generuje nietypowe zyski i czy warto ją śledzić. Analiza ta obejmuje okres jednego roku po każdej transakcji wyniki są teoretyczne .
Poniższa tabela przedstawia najnowsze zakupy na otwartym rynku, które nie były częścią planu handlu automatycznego.
Cena skorygowana to cena skorygowana o podział. Akcje skorygowane to akcje skorygowane o podział.
Śledź historię sprzedaży insider — analiza strat krótkoterminowych
W tej sekcji analizujemy możliwość uniknięcia krótkoterminowych strat w wyniku każdej nieplanowanej sprzedaży insidera na otwartym rynku dokonanej w PIRS / Pieris Pharmaceuticals, Inc.. Konsekwentny wzorzec unikania strat może sugerować, że przyszłe transakcje sprzedaży mogą przewidywać spadki cen. Analiza ta obejmuje okres jednego roku po każdej transakcji wyniki są teoretyczne .
Poniższa tabela przedstawia najnowsze sprzedaże na otwartym rynku, które nie były częścią planu handlu automatycznego.
Cena skorygowana to cena skorygowana o podział. Akcje skorygowane to akcje skorygowane o podział.
Historia transakcji
Kliknij ikonę linku, aby zobaczyć pełną historię transakcji. Transakcje zgłoszone w ramach automatycznego planu handlowego 10b5-1 będą oznaczone znakiem X w kolumnie oznaczonej 10b-5.
| Plik Data |
Data transakcji |
Formularz | Wtajemniczony | Serce | Nazwa papieru wartościowego | Kod | Bezpośredni | Cena wykonania |
Cena jednostki |
Zmieniono jednostki |
Zmieniona wartość (1 tys.) |
Pozostałe opcje |
Pozostałe akcje |
|
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2026-05-22 | 2026-05-20 | 4 | Goin Kathleen | PVLA | Common Stock | D | 111,8950 | -48 | -5 | 0 | ||||
| 2026-05-22 | 2026-05-20 | 4 | Goin Kathleen | PVLA | Common Stock | D | 111,2963 | -891 | -99 | 48 | ||||
| 2026-05-22 | 2026-05-20 | 4 | Goin Kathleen | PVLA | Common Stock | D | 110,3464 | -3 363 | -371 | 939 | ||||
| 2026-05-22 | 2026-05-20 | 4 | Goin Kathleen | PVLA | Common Stock | D | 9,0800 | 2 148 | 20 | 4 302 | ||||
| 2026-05-22 | 2026-05-20 | 4 | Goin Kathleen | PVLA | Common Stock | D | 7,1400 | 2 154 | 15 | 2 154 | ||||
| 2026-04-17 | 2026-04-15 | 4 | Goin Kathleen | PVLA | Common Stock | D | 130,3300 | -100 | -13 | 0 | ||||
| 2026-04-17 | 2026-04-15 | 4 | Goin Kathleen | PVLA | Common Stock | D | 129,1692 | -639 | -83 | 100 | ||||
| 2026-04-17 | 2026-04-15 | 4 | Goin Kathleen | PVLA | Common Stock | D | 128,2349 | -561 | -72 | 739 | ||||
| 2026-04-17 | 2026-04-15 | 4 | Goin Kathleen | PVLA | Common Stock | D | 127,1254 | -1 500 | -191 | 1 300 | ||||
| 2026-04-17 | 2026-04-15 | 4 | Goin Kathleen | PVLA | Common Stock | D | 125,9647 | -1 502 | -189 | 2 800 | ||||
| 2026-04-17 | 2026-04-15 | 4 | Goin Kathleen | PVLA | Common Stock | D | 9,0800 | 2 148 | 20 | 4 302 | ||||
| 2026-04-17 | 2026-04-15 | 4 | Goin Kathleen | PVLA | Common Stock | D | 7,1400 | 2 154 | 15 | 2 154 | ||||
| 2026-04-01 | 2026-03-30 | 4 | JENKINS GEORGE M | PVLA | Common Stock | D | 112,3000 | 445 | 50 | 187 616 | ||||
| 2026-03-20 | 2026-03-18 | 4 | Goin Kathleen | PVLA | Common Stock | D | 119,0817 | -304 | -36 | 0 | ||||
| 2026-03-20 | 2026-03-18 | 4 | Goin Kathleen | PVLA | Common Stock | D | 118,3681 | -1 730 | -205 | 304 | ||||
| 2026-03-20 | 2026-03-18 | 4 | Goin Kathleen | PVLA | Common Stock | D | 117,5632 | -2 268 | -267 | 2 034 | ||||
| 2026-03-20 | 2026-03-18 | 4 | Goin Kathleen | PVLA | Common Stock | D | 9,0800 | 2 148 | 20 | 4 302 | ||||
| 2026-03-20 | 2026-03-18 | 4 | Goin Kathleen | PVLA | Common Stock | D | 7,1400 | 2 154 | 15 | 2 154 | ||||
| 2026-03-02 | 2026-02-27 | 4 | JENKINS GEORGE M | PVLA | Common Stock | D | 125,0000 | 4 000 | 500 | 187 171 | ||||
| 2026-03-02 | 2026-02-27 | 4 | HERON ELAINE J | PVLA | Common Stock | D | 125,0000 | 2 400 | 300 | 47 812 | ||||
| 2026-02-20 | 2026-02-18 | 4 | Goin Kathleen | PVLA | Common Stock | D | 79,9651 | -1 276 | -102 | 0 | ||||
| 2026-02-20 | 2026-02-18 | 4 | Goin Kathleen | PVLA | Common Stock | D | 79,1569 | -3 026 | -240 | 1 276 | ||||
| 2026-02-20 | 2026-02-18 | 4 | Goin Kathleen | PVLA | Common Stock | D | 9,0800 | 2 148 | 20 | 4 302 | ||||
| 2026-02-20 | 2026-02-18 | 4 | Goin Kathleen | PVLA | Common Stock | D | 7,1400 | 2 154 | 15 | 2 154 | ||||
| 2026-01-23 | 2026-01-21 | 4 | Goin Kathleen | PVLA | Common Stock | D | 97,9400 | -3 749 | -367 | 0 | ||||
| 2026-01-23 | 2026-01-21 | 4 | Goin Kathleen | PVLA | Common Stock | D | 95,4900 | -553 | -53 | 3 749 | ||||
| 2026-01-23 | 2026-01-21 | 4 | Goin Kathleen | PVLA | Common Stock | D | 9,0800 | 2 148 | 20 | 4 302 | ||||
| 2026-01-23 | 2026-01-21 | 4 | Goin Kathleen | PVLA | Common Stock | D | 7,1400 | 2 154 | 15 | 2 154 | ||||
| 2025-12-19 | 2025-12-17 | 4 | Goin Kathleen | PVLA | Common Stock | D | 96,4720 | -4 302 | -415 | 0 | ||||
| 2025-12-19 | 2025-12-17 | 4 | Goin Kathleen | PVLA | Common Stock | D | 9,0800 | 2 148 | 20 | 4 302 | ||||
| 2025-12-19 | 2025-12-17 | 4 | Goin Kathleen | PVLA | Common Stock | D | 7,1400 | 2 154 | 15 | 2 154 | ||||
| 2025-11-21 | 2025-11-19 | 4 | Goin Kathleen | PVLA | Common Stock | D | 86,5053 | -2 802 | -242 | 0 | ||||
| 2025-11-21 | 2025-11-19 | 4 | Goin Kathleen | PVLA | Common Stock | D | 85,7183 | -1 500 | -129 | 2 802 | ||||
| 2025-11-21 | 2025-11-19 | 4 | Goin Kathleen | PVLA | Common Stock | D | 9,0800 | 2 148 | 20 | 4 302 | ||||
| 2025-11-21 | 2025-11-19 | 4 | Goin Kathleen | PVLA | Common Stock | D | 7,1400 | 2 154 | 15 | 2 154 | ||||
| 2025-04-10 | 2025-04-09 | 4 | JENKINS GEORGE M by foundation | PVLA | Common Stock | I | 20,2700 | 2 490 | 50 | 13 516 | ||||
| 2025-04-10 | 2025-04-09 | 4 | JENKINS GEORGE M | PVLA | Common Stock | D | 20,1300 | 2 500 | 50 | 183 171 | ||||
| 2025-01-06 | 3/A | Kaupinen Wes | PVLA | Common Stock | D | 44 410 | ||||||||
| 2024-12-19 | 2024-12-18 | 4 | JENKINS GEORGE M | PVLA | Common Stock | D | 12,9300 | 4 000 | 52 | 180 671 | ||||
| 2024-12-17 | 2024-12-13 | 4 | BVF PARTNERS L P/IL | PVLA | Common Stock, $0.001 par value | D | 29 648 | 38 961 | ||||||
| 2024-12-17 | 2024-12-13 | 4 | BVF PARTNERS L P/IL | PVLA | Common Stock, $0.001 par value | D | 174 958 | 282 223 | ||||||
| 2024-12-17 | 2024-12-13 | 4 | BVF PARTNERS L P/IL | PVLA | Common Stock, $0.001 par value | D | 234 323 | 371 916 | ||||||
| 2024-12-16 | 3 | Kaupinen Wes | PVLA | Common Stock | D | 42 940 | ||||||||
| 2024-12-16 | 3 | Kaupinen Wes by Christine L. Kaupinen 2019 Irrevocable Trust dated February 28, 2019 | PVLA | Common Stock | I | 781 409 | ||||||||
| 2024-12-16 | 3 | Kaupinen Wes by Wesley H. Kaupinen 2019 Irrevocable Trust dated February 28, 2019 | PVLA | Common Stock | I | 781 409 | ||||||||
| 2024-12-16 | 3 | Davis Todd C | PVLA | Common Stock | D | 112 547 | ||||||||
| 2024-12-16 | 3 | JENKINS GEORGE M by Eagles Mere Air Museum Foundation | PVLA | Common Stock | I | 11 026 | ||||||||
| 2024-12-16 | 3 | JENKINS GEORGE M | PVLA | Common Stock | D | 176 671 | ||||||||
| 2024-12-16 | 3 | HERON ELAINE J | PVLA | Common Stock | D | 45 412 | ||||||||
| 2024-12-16 | 3 | HERON ELAINE J by Trust | PVLA | Common Stock | I | 5 879 | ||||||||
| 2024-12-12 | 2024-12-12 | 4 | GERAGHTY JAMES A | PIRS | Series F Preferred Stock, par value $0.001 per share | D | 0,0100 | -1 | -0 | 0 | ||||
| 2024-11-18 | 3 | Dellora Investments LP | PIRS | Common Stock | I | 141 079 | ||||||||
| 2024-10-28 | 2024-08-07 | 4 | GERAGHTY JAMES A | PIRS | Series F Preferred Stock, par value $0.001 per share | D | 1,0000 | 1 | 0 | 1 | ||||
| 2024-08-12 | 2024-08-12 | 4 | ADAR1 Capital Management, LLC By: Spearhead Insurance Solutions IDF, LLC - Series ADAR1 | PIRS | Common Stock | I | 15,8824 | 757 | 12 | 15 067 | ||||
| 2024-08-12 | 2024-08-12 | 4 | ADAR1 Capital Management, LLC By: ADAR1 Partners | PIRS | Common Stock | I | 15,8824 | 2 243 | 36 | 129 574 | ||||
| 2024-08-12 | 2024-08-09 | 4 | ADAR1 Capital Management, LLC By: ADAR1 Partners | PIRS | Common Stock | I | 14,8929 | 3 000 | 45 | 127 331 | ||||
| 2024-07-31 | 3 | ADAR1 Capital Management, LLC By: Spearhead Insurance Solutions IDF, LLC - Series ADAR1 | PIRS | Common Stock | I | 14 310 | ||||||||
| 2024-07-31 | 3 | ADAR1 Capital Management, LLC By: ADAR1 Partners | PIRS | Common Stock | I | 124 331 | ||||||||
| 2023-05-30 | 2023-05-25 | 4 | KIRITSY CHRISTOPHER P | PIRS | Common Stock | D | 0,8500 | 10 000 | 8 | 20 000 | ||||
| 2023-05-22 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 8 581 171 | ||||||||
| 2023-05-22 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 744 966 | ||||||||
| 2023-05-22 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 11 007 420 | ||||||||
| 2022-05-16 | 2022-05-13 | 4 | Demuth Tim | PIRS | Common Stock | D | 1,7100 | 6 000 | 10 | 6 000 | ||||
| 2022-02-24 | 2022-02-22 | 4 | Yoder Stephen S. | PIRS | Stock Option (Right to buy) | D | 3,03 | 625 874 | 625 874 | |||||
| 2022-02-24 | 2022-02-22 | 4 | Mousa Ahmed | PIRS | Stock Option (Right to buy) | D | 3,03 | 215 819 | 215 819 | |||||
| 2022-02-24 | 2022-02-22 | 4 | Olwill Shane | PIRS | Stock Option (Right to buy) | D | 3,03 | 215 819 | 215 819 | |||||
| 2022-02-24 | 2022-02-22 | 4 | Demuth Tim | PIRS | Stock Option (Right to buy) | D | 3,03 | 100 000 | 100 000 | |||||
| 2022-02-24 | 2022-02-22 | 4 | Kaufmann Hitto | PIRS | Stock Option (Right to buy) | D | 3,03 | 215 819 | 215 819 | |||||
| 2022-02-24 | 2022-02-22 | 4 | Bures Thomas | PIRS | Stock Options (Right to buy) | D | 3,03 | 215 819 | 215 819 | |||||
| 2021-09-01 | 2021-08-30 | 4 | Olwill Shane | PIRS | Stock Option (right to buy) | D | 1,52 | -38 400 | 61 600 | |||||
| 2021-09-01 | 2021-08-30 | 4 | Olwill Shane | PIRS | Common Stock | D | 5,1500 | -29 200 | -150 | 4 638 | ||||
| 2021-09-01 | 2021-08-30 | 4 | Olwill Shane | PIRS | Common Stock | D | 5,0000 | -9 200 | -46 | 33 838 | ||||
| 2021-09-01 | 2021-08-30 | 4 | Olwill Shane | PIRS | Common Stock | D | 1,5200 | 38 400 | 58 | 43 038 | ||||
| 2021-08-03 | 2021-08-01 | 4 | Demuth Tim | PIRS | Stock Option (right to buy) | D | 3,48 | 360 000 | 360 000 | |||||
| 2021-08-03 | 3 | Olwill Shane | PIRS | Common Stock | D | 4 638 | ||||||||
| 2021-06-29 | 2021-06-25 | 4 | Sherman Matthew L | PIRS | Stock Option (right to buy) | D | 4,00 | 40 000 | 40 000 | |||||
| 2021-06-29 | 2021-06-25 | 4 | Said Maya R. | PIRS | Stock Option (right to buy) | D | 4,00 | 40 000 | 40 000 | |||||
| 2021-06-29 | 2021-06-25 | 4 | Richman Michael | PIRS | Stock Option (right to buy) | D | 4,00 | 40 000 | 40 000 | |||||
| 2021-06-29 | 2021-06-25 | 4 | KIRITSY CHRISTOPHER P | PIRS | Stock Option (right to buy) | D | 4,00 | 40 000 | 40 000 | |||||
| 2021-06-29 | 2021-06-25 | 4 | Kiener Peter A | PIRS | Stock Option (right to buy) | D | 4,00 | 40 000 | 40 000 | |||||
| 2021-06-29 | 2021-06-25 | 4 | GERAGHTY JAMES A | PIRS | Stock Option (right to buy) | D | 4,00 | 45 000 | 45 000 | |||||
| 2021-06-29 | 2021-06-25 | 4 | Barbier Ann | PIRS | Stock Option (right to buy) | D | 4,00 | 40 000 | 40 000 | |||||
| 2021-03-08 | 2021-03-04 | 4 | Bures Thomas | PIRS | Stock Options (Right to buy) | D | 2,50 | 150 000 | 150 000 | |||||
| 2021-03-08 | 2021-03-04 | 4 | Yoder Stephen S. | PIRS | Stock Options (Right to buy) | D | 2,50 | 530 000 | 530 000 | |||||
| 2021-03-08 | 2021-03-04 | 4 | Kaufmann Hitto | PIRS | Stock Options (Right to buy) | D | 2,50 | 220 000 | 220 000 | |||||
| 2020-07-22 | 2020-07-21 | 4 | Aquilo Capital Management, LLC See footnotes | PIRS | Common Stock, $0.001 par value | I | 2,9500 | -1 900 000 | -5 605 | 3 675 530 | ||||
| 2020-06-25 | 2020-06-23 | 4/A | Said Maya R. | PIRS | Stock Option (right to buy) | D | 3,27 | 40 000 | 40 000 | |||||
| 2020-06-25 | 2020-06-23 | 4/A | KIRITSY CHRISTOPHER P | PIRS | Stock Option (right to buy) | D | 3,27 | 40 000 | 40 000 | |||||
| 2020-06-25 | 2020-06-23 | 4 | Kiener Peter A | PIRS | Stock Options (Right to buy) | D | 3,27 | 40 000 | 40 000 | |||||
| 2020-06-25 | 2020-06-23 | 4 | KIRITSY CHRISTOPHER P | PIRS | Stock Option (right to buy) | D | 3,27 | 40 000 | 40 000 | |||||
| 2020-06-25 | 2020-06-23 | 4 | Richman Michael | PIRS | Stock Option (right to buy) | D | 3,27 | 40 000 | 40 000 | |||||
| 2020-06-25 | 2020-06-23 | 4 | Sherman Matthew L | PIRS | Stock Option (right to buy) | D | 3,27 | 40 000 | 40 000 | |||||
| 2020-06-25 | 2020-06-25 | 4 | Said Maya R. | PIRS | Stock Option (right to buy) | D | 3,27 | 40 000 | 40 000 | |||||
| 2020-06-25 | 2020-06-23 | 4 | Barbier Ann | PIRS | Stock Options (Right to buy) | D | 3,27 | 40 000 | 40 000 | |||||
| 2020-06-25 | 2020-06-23 | 4 | GERAGHTY JAMES A | PIRS | Stock Option (right to buy) | D | 3,27 | 45 000 | 45 000 | |||||
| 2020-03-23 | 3 | Aquilo Capital Management, LLC See footnotes | PIRS | Common Stock, $0.001 par value | I | 11 151 060 | ||||||||
| 2020-03-23 | 3 | Aquilo Capital Management, LLC See footnotes | PIRS | Common Stock, $0.001 par value | I | 11 151 060 | ||||||||
| 2020-03-23 | 3 | Aquilo Capital Management, LLC See footnotes | PIRS | Common Stock, $0.001 par value | I | 11 151 060 | ||||||||
| 2020-03-02 | 2020-02-27 | 4 | Yoder Stephen S. | PIRS | Stock Option (Right to Buy) | D | 3,15 | 420 000 | 420 000 | |||||
| 2020-03-02 | 2020-02-27 | 4 | Kaufmann Hitto | PIRS | Stock Option (Right to Buy) | D | 3,15 | 45 000 | 45 000 | |||||
| 2020-03-02 | 2020-02-27 | 4 | Bures Thomas | PIRS | Stock Option (Right to Buy) | D | 3,15 | 80 000 | 80 000 | |||||
| 2020-01-28 | 2020-01-25 | 4 | GERAGHTY JAMES A | PIRS | Stock Option (right to buy) | D | 3,23 | 22 500 | 22 500 | |||||
| 2020-01-28 | 2020-01-25 | 4 | Richman Michael | PIRS | Stock Option (right to buy) | D | 3,23 | 20 000 | 20 000 | |||||
| 2020-01-28 | 2020-01-25 | 4 | Richman Michael | PIRS | Stock Option (right to buy) | D | 3,23 | 2,1070 | 5 431 | 11 | 5 431 | |||
| 2020-01-28 | 2020-01-25 | 4 | BIZZARI JEAN-PIERRE | PIRS | Stock Option (right to buy) | D | 3,23 | 20 000 | 20 000 | |||||
| 2020-01-28 | 2020-01-25 | 4 | KIRITSY CHRISTOPHER P | PIRS | Stock Option (right to buy) | D | 3,23 | 20 000 | 20 000 | |||||
| 2020-01-28 | 2020-01-25 | 4 | Barbier Ann | PIRS | Stock Option (right to buy) | D | 3,23 | 20 000 | 20 000 | |||||
| 2020-01-28 | 2020-01-25 | 4 | Kiener Peter A | PIRS | Stock Option (right to buy) | D | 3,23 | 20 000 | 20 000 | |||||
| 2020-01-28 | 2020-01-25 | 4 | Said Maya R. | PIRS | Stock Option (right to buy) | D | 3,23 | 20 000 | 20 000 | |||||
| 2020-01-28 | 2020-01-25 | 4 | Sherman Matthew L | PIRS | Stock Option (right to buy) | D | 3,23 | 20 000 | 20 000 | |||||
| 2019-10-28 | 2019-10-25 | 4 | Richman Michael | PIRS | Stock Options (right to buy) | D | 3,24 | 2,1180 | 5 165 | 11 | 5 165 | |||
| 2019-09-10 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 7 241 062 | ||||||||
| 2019-09-10 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 5 297 535 | ||||||||
| 2019-09-10 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 5 297 535 | ||||||||
| 2019-09-10 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 7 241 062 | ||||||||
| 2019-09-10 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 7 390 475 | ||||||||
| 2019-09-10 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 5 297 535 | ||||||||
| 2019-09-10 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 5 297 535 | ||||||||
| 2019-09-10 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 7 241 062 | ||||||||
| 2019-09-10 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 7 390 475 | ||||||||
| 2019-09-10 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 5 297 535 | ||||||||
| 2019-09-10 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 7 241 062 | ||||||||
| 2019-09-10 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 7 390 475 | ||||||||
| 2019-09-10 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 5 297 535 | ||||||||
| 2019-09-10 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 7 241 062 | ||||||||
| 2019-09-10 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 7 390 475 | ||||||||
| 2019-09-10 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 7 390 475 | ||||||||
| 2019-09-10 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 7 241 062 | ||||||||
| 2019-09-10 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 5 297 535 | ||||||||
| 2019-09-10 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 7 390 475 | ||||||||
| 2019-09-10 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 7 241 062 | ||||||||
| 2019-09-10 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 5 297 535 | ||||||||
| 2019-09-10 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 7 390 475 | ||||||||
| 2019-09-10 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 7 241 062 | ||||||||
| 2019-09-10 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 7 390 475 | ||||||||
| 2019-09-10 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 7 241 062 | ||||||||
| 2019-09-10 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 5 297 535 | ||||||||
| 2019-09-10 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 7 390 475 | ||||||||
| 2019-09-10 | 2019-09-06 | 4 | BVF PARTNERS L P/IL | PIRS | Common Stock, $0.001 par value | D | 4,4994 | -1 128 | -5 | 314 139 | ||||
| 2019-09-10 | 2019-09-06 | 4 | BVF PARTNERS L P/IL | PIRS | Common Stock, $0.001 par value | D | 4,4994 | -25 720 | -116 | 2 233 074 | ||||
| 2019-09-10 | 2019-09-06 | 4 | BVF PARTNERS L P/IL | PIRS | Common Stock, $0.001 par value | D | 4,4994 | -23 152 | -104 | 2 385 055 | ||||
| 2019-09-03 | 3 | Bures Thomas | PIRS | Common Stock | D | 10 218 | ||||||||
| 2019-09-03 | 3 | Bures Thomas | PIRS | Common Stock | D | 10 218 | ||||||||
| 2019-09-03 | 3 | Bures Thomas | PIRS | Common Stock | D | 10 218 | ||||||||
| 2019-09-03 | 2019-08-30 | 4 | Kaufmann Hitto | PIRS | Stock Option (right to buy) | D | 4,65 | 300 000 | 300 000 | |||||
| 2019-08-01 | 2019-07-31 | 4 | Said Maya R. | PIRS | Stock Option (right to buy) | D | 5,50 | 30 000 | 30 000 | |||||
| 2019-07-26 | 2019-07-25 | 4 | Richman Michael | PIRS | Stock Option (right to buy) | D | 4,40 | 2,8900 | 3 789 | 11 | 3 789 | |||
| 2019-04-30 | 2019-04-25 | 4 | Richman Michael | PIRS | Stock Option (right to buy) | D | 2,94 | 1,9400 | 5 640 | 11 | 5 640 | |||
| 2019-02-28 | 2019-02-26 | 4 | Yoder Stephen S. | PIRS | Stock Options (Right to Buy) | D | 3,09 | 380 000 | 380 000 | |||||
| 2019-02-28 | 2019-02-26 | 4 | Reine Allan | PIRS | Stock Options (Right to Buy) | D | 3,09 | 162 500 | 162 500 | |||||
| 2019-02-28 | 2019-02-26 | 4 | Matis Louis | PIRS | Stock Option (Right to Buy) | D | 3,09 | 96 500 | 96 500 | |||||
| 2019-02-01 | 2019-01-30 | 4 | BVF PARTNERS L P/IL | PIRS | Series B Convertible Preferred Stock, $0.001 par value | D | 284 | 284 | ||||||
| 2019-02-01 | 2019-01-30 | 4 | BVF PARTNERS L P/IL | PIRS | Series B Convertible Preferred Stock, $0.001 par value | D | 2 143 | 2 143 | ||||||
| 2019-02-01 | 2019-01-30 | 4 | BVF PARTNERS L P/IL | PIRS | Series B Convertible Preferred Stock, $0.001 par value | D | 2 573 | 2 573 | ||||||
| 2019-02-01 | 2019-01-30 | 4 | BVF PARTNERS L P/IL | PIRS | Common Stock, $0.001 par value | D | -284 000 | 141 346 | ||||||
| 2019-02-01 | 2019-01-30 | 4 | BVF PARTNERS L P/IL | PIRS | Common Stock, $0.001 par value | D | -2 143 000 | 772 324 | ||||||
| 2019-02-01 | 2019-01-30 | 4 | BVF PARTNERS L P/IL | PIRS | Common Stock, $0.001 par value | D | -2 573 000 | 978 200 | ||||||
| 2019-01-29 | 2019-01-25 | 4 | GERAGHTY JAMES A | PIRS | Stock Option (right to buy) | D | 2,74 | 25 000 | 25 000 | |||||
| 2019-01-29 | 2019-01-25 | 4 | Barbier Ann | PIRS | Stock Option (right to buy) | D | 2,74 | 20 000 | 20 000 | |||||
| 2019-01-29 | 2019-01-25 | 4 | BIZZARI JEAN-PIERRE | PIRS | Stock Option (right to buy) | D | 2,74 | 20 000 | 20 000 | |||||
| 2019-01-29 | 2019-01-25 | 4 | Kiener Peter A | PIRS | Stock Option (right to buy) | D | 2,74 | 20 000 | 20 000 | |||||
| 2019-01-29 | 2019-01-25 | 4 | KIRITSY CHRISTOPHER P | PIRS | Stock Option (right to buy) | D | 2,74 | 20 000 | 20 000 | |||||
| 2019-01-29 | 2019-01-25 | 4 | Prelack Steven | PIRS | Stock Option (right to buy) | D | 2,74 | 20 000 | 20 000 | |||||
| 2019-01-29 | 2019-01-25 | 4 | Richman Michael | PIRS | Stock Option (right to buy) | D | 2,74 | 20 000 | 20 000 | |||||
| 2019-01-29 | 2019-01-25 | 4 | Richman Michael | PIRS | Stock Option (right to buy) | D | 2,74 | 1,7900 | 6 096 | 11 | 6 096 | |||
| 2019-01-29 | 2019-01-25 | 4 | Sherman Matthew L | PIRS | Stock Option (right to buy) | D | 2,74 | 20 000 | 20 000 | |||||
| 2018-11-26 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 10 443 070 | ||||||||
| 2018-11-26 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 9 807 194 | ||||||||
| 2018-11-26 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 7 317 216 | ||||||||
| 2018-11-26 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 9 807 194 | ||||||||
| 2018-11-26 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 7 317 216 | ||||||||
| 2018-11-26 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 10 443 070 | ||||||||
| 2018-11-26 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 10 443 070 | ||||||||
| 2018-11-26 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 9 807 194 | ||||||||
| 2018-11-26 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 7 317 216 | ||||||||
| 2018-11-26 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 10 443 070 | ||||||||
| 2018-11-26 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 9 807 194 | ||||||||
| 2018-11-26 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 7 317 216 | ||||||||
| 2018-11-26 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 10 443 070 | ||||||||
| 2018-11-26 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 9 807 194 | ||||||||
| 2018-11-26 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 7 317 216 | ||||||||
| 2018-11-26 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 10 443 070 | ||||||||
| 2018-11-26 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 9 807 194 | ||||||||
| 2018-11-26 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 7 317 216 | ||||||||
| 2018-11-26 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 10 443 070 | ||||||||
| 2018-11-26 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 9 807 194 | ||||||||
| 2018-11-26 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 7 317 216 | ||||||||
| 2018-11-26 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 10 443 070 | ||||||||
| 2018-11-26 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 9 807 194 | ||||||||
| 2018-11-26 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 7 317 216 | ||||||||
| 2018-11-26 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 10 443 070 | ||||||||
| 2018-11-26 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 9 807 194 | ||||||||
| 2018-11-26 | 3 | LAMPERT MARK N | PIRS | Common Stock, $0.001 par value | D | 7 317 216 | ||||||||
| 2018-10-29 | 2018-10-25 | 4 | Richman Michael | PIRS | Stock Option (right to buy) | D | 4,36 | 2,8600 | 3 829 | 11 | 3 829 | |||
| 2018-10-25 | 2018-10-24 | 4 | Kiener Peter A | PIRS | Stock Option (right to buy) | D | 4,46 | 30 000 | 30 000 | |||||
| 2018-10-25 | 2018-10-24 | 4 | Sherman Matthew L | PIRS | Stock Option (right to buy) | D | 4,46 | 30 000 | 30 000 | |||||
| 2018-09-17 | 2018-09-14 | 4 | KIRITSY CHRISTOPHER P | PIRS | Common Stock | D | 5,1050 | 5 000 | 26 | 10 000 | ||||
| 2018-07-26 | 2018-07-25 | 4 | Richman Michael | PIRS | Stock Option (right to buy) | D | 5,92 | 3,8600 | 2 837 | 11 | 2 837 | |||
| 2018-05-16 | 2018-05-15 | 4 | GERAGHTY JAMES A | PIRS | Common Stock | D | 5,7500 | 10 000 | 58 | 20 000 | ||||
| 2018-05-02 | 2018-04-30 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Common Stock | I | 6,3500 | -10 400 | -66 | 38 870 | ||||
| 2018-05-02 | 2018-04-30 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Common Stock | I | 6,3500 | -989 600 | -6 284 | 4 511 130 | ||||
| 2018-04-26 | 2018-04-25 | 4 | Barbier Ann | PIRS | Stock Option (right to buy) | D | 6,43 | 30 000 | 30 000 | |||||
| 2018-04-26 | 2018-04-25 | 4 | Richman Michael | PIRS | Stock Option (right to buy) | D | 6,43 | 4,1000 | 2 665 | 11 | 2 665 | |||
| 2018-02-26 | 2018-02-20 | 4 | Yoder Stephen S. | PIRS | Stock Options (Right to buy) | D | 8,56 | 325 000 | 325 000 | |||||
| 2018-02-26 | 2018-02-20 | 4 | Reine Allan | PIRS | Stock Options (Right to buy) | D | 5,00 | 50 000 | 50 000 | |||||
| 2018-02-26 | 2018-02-20 | 4 | Reine Allan | PIRS | Stock Options (Right to buy) | D | 8,56 | 53 833 | 53 833 | |||||
| 2018-02-26 | 2018-02-20 | 4 | Matis Louis | PIRS | Stock Options (Right to buy) | D | 8,56 | 100 000 | 100 000 | |||||
| 2018-02-15 | 2018-02-13 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Stock Option (right to buy) | I | 5,08 | -17 | 0 | |||||
| 2018-02-15 | 2018-02-13 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Stock Option (right to buy) | I | 5,08 | -1 765 | 0 | |||||
| 2018-02-15 | 2018-02-13 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Stock Option (right to buy) | I | 4,68 | -58 | 0 | |||||
| 2018-02-15 | 2018-02-13 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Stock Option (right to buy) | I | 4,68 | -6 057 | 0 | |||||
| 2018-02-15 | 2018-02-13 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Common Stock | I | 8,9800 | -75 | -1 | 49 270 | ||||
| 2018-02-15 | 2018-02-13 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Common Stock | I | 8,9800 | -7 822 | -70 | 5 500 730 | ||||
| 2018-02-15 | 2018-02-13 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Common Stock | I | 5,0800 | 17 | 0 | 49 345 | ||||
| 2018-02-15 | 2018-02-13 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Common Stock | I | 5,0800 | 1 765 | 9 | 5 508 552 | ||||
| 2018-02-15 | 2018-02-13 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Common Stock | I | 4,6800 | 58 | 0 | 49 328 | ||||
| 2018-02-15 | 2018-02-13 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Common Stock | I | 4,6800 | 6 057 | 28 | 5 506 787 | ||||
| 2018-01-29 | 2018-01-25 | 4 | GERAGHTY JAMES A | PIRS | Stock Option (right to buy) | D | 7,72 | 25 000 | 25 000 | |||||
| 2018-01-29 | 2018-01-25 | 4 | Prelack Steven | PIRS | Stock Option (right to buy) | D | 7,72 | 20 000 | 20 000 | |||||
| 2018-01-29 | 2018-01-25 | 4 | Richman Michael | PIRS | Stock Option (right to buy) | D | 7,72 | 20 000 | 20 000 | |||||
| 2018-01-29 | 2018-01-25 | 4 | Richman Michael | PIRS | Stock Option (right to buy) | D | 7,72 | 5,0900 | 2 243 | 11 | 2 243 | |||
| 2018-01-29 | 2018-01-25 | 4 | BIZZARI JEAN-PIERRE | PIRS | Stock Option (right to buy) | D | 7,72 | 20 000 | 20 000 | |||||
| 2018-01-29 | 2018-01-25 | 4 | ADAMS JULIAN | PIRS | Stock Option (right to buy) | D | 7,72 | 20 000 | 20 000 | |||||
| 2018-01-29 | 2018-01-25 | 4 | KIRITSY CHRISTOPHER P | PIRS | Stock Option (right to buy) | D | 7,72 | 20 000 | 20 000 | |||||
| 2018-01-04 | 2018-01-03 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Common Stock | I | 7,3500 | -16 128 | -119 | 49 270 | ||||
| 2018-01-04 | 2018-01-03 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Common Stock | I | 7,3500 | -1 693 492 | -12 447 | 5 500 730 | ||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Stock Option (right to buy) | I | 5,64 | -47 | 0 | |||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Stock Option (right to buy) | I | 5,64 | -4 971 | 0 | |||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Stock Option (right to buy) | I | 2,32 | -99 | 0 | |||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Stock Option (right to buy) | I | 2,32 | -10 447 | 0 | |||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Stock Option (right to buy) | I | 1,62 | -97 | 0 | |||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Stock Option (right to buy) | I | 2,01 | -97 | 0 | |||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Stock Option (right to buy) | I | 2,01 | -10 216 | 0 | |||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Stock Option (right to buy) | I | 2,01 | -142 | 0 | |||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Stock Option (right to buy) | I | 2,01 | -14 858 | 0 | |||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Stock Option (right to buy) | I | 1,64 | -97 | 0 | |||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Stock Option (right to buy) | I | 1,64 | -10 182 | 0 | |||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Stock Option (right to buy) | I | 1,73 | -92 | 0 | |||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Stock Option (right to buy) | I | 1,73 | -9 642 | 0 | |||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Stock Option (right to buy) | I | 2,05 | -77 | 0 | |||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Stock Option (right to buy) | I | 2,05 | -8 097 | 0 | |||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Stock Option (right to buy) | I | 1,59 | -189 | 0 | |||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Stock Option (right to buy) | I | 1,59 | -19 811 | 0 | |||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Stock Option (right to buy) | I | 1,62 | -10 180 | 0 | |||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Stock Option (right to buy) | I | 1,94 | -83 | 0 | |||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Stock Option (right to buy) | I | 1,94 | -8 717 | 0 | |||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Stock Option (right to buy) | I | 2,62 | -63 | 0 | |||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Stock Option (right to buy) | I | 2,62 | -6 654 | 0 | |||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Stock Option (right to buy) | I | 3,00 | -50 | 0 | |||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Stock Option (right to buy) | I | 3,00 | -5 227 | 0 | |||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Stock Option (right to buy) | I | 2,00 | -259 | 0 | |||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Stock Option (right to buy) | I | 2,00 | -27 241 | 0 | |||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Common Stock | I | 5,7000 | -1 392 | -8 | 65 398 | ||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Common Stock | I | 5,7000 | -146 243 | -834 | 7 194 222 | ||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Common Stock | I | 5,6400 | 47 | 0 | 66 790 | ||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Common Stock | I | 5,6400 | 4 971 | 28 | 7 340 465 | ||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Common Stock | I | 2,3200 | 99 | 0 | 66 743 | ||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Common Stock | I | 2,3200 | 10 447 | 24 | 7 335 494 | ||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Common Stock | I | 2,0100 | 97 | 0 | 66 644 | ||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Common Stock | I | 2,0100 | 10 216 | 21 | 7 325 047 | ||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Common Stock | I | 2,0100 | 142 | 0 | 66 547 | ||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Common Stock | I | 2,0100 | 14 858 | 30 | 7 314 831 | ||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Common Stock | I | 1,6400 | 97 | 0 | 66 405 | ||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Common Stock | I | 1,6400 | 10 182 | 17 | 7 299 973 | ||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Common Stock | I | 1,7300 | 92 | 0 | 66 308 | ||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Common Stock | I | 1,7300 | 9 642 | 17 | 7 289 791 | ||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Common Stock | I | 2,0500 | 77 | 0 | 66 216 | ||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Common Stock | I | 2,0500 | 8 097 | 17 | 7 280 149 | ||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Common Stock | I | 1,5900 | 189 | 0 | 66 139 | ||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Common Stock | I | 1,5900 | 19 811 | 31 | 7 272 052 | ||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Common Stock | I | 1,6200 | 97 | 0 | 65 950 | ||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Common Stock | I | 1,6200 | 10 180 | 16 | 7 252 241 | ||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Common Stock | I | 1,9400 | 83 | 0 | 65 853 | ||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Common Stock | I | 1,9400 | 8 717 | 17 | 7 242 061 | ||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Common Stock | I | 2,6200 | 63 | 0 | 65 770 | ||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Common Stock | I | 2,6200 | 6 654 | 17 | 7 233 344 | ||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Common Stock | I | 3,0000 | 50 | 0 | 65 707 | ||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Common Stock | I | 3,0000 | 5 227 | 16 | 7 226 690 | ||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Common Stock | I | 2,0000 | 259 | 1 | 65 657 | ||||
| 2017-12-20 | 2017-12-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Common Stock | I | 2,0000 | 27 241 | 54 | 7 221 463 | ||||
| 2017-12-14 | 2017-12-12 | 4 | GERAGHTY JAMES A | PIRS | Stock Option (right to buy) | D | 5,79 | 40 000 | 40 000 | |||||
| 2017-10-27 | 2017-10-25 | 4 | Khuong Chau Quang | PIRS | Stock Options (Right to buy) | D | 4,68 | 6 115 | 6 115 | |||||
| 2017-10-27 | 2017-10-25 | 4 | Richman Michael | PIRS | Stock Option (Rights to buy) | D | 4,68 | 4 006 | 4 006 | |||||
| 2017-08-17 | 2017-08-17 | 4 | Reine Allan | PIRS | Common Stock | D | 4,8900 | 20 000 | 98 | 65 000 | ||||
| 2017-08-17 | 2017-08-16 | 4 | Reine Allan | PIRS | Common Stock | D | 4,7900 | 45 000 | 216 | 45 000 | ||||
| 2017-08-17 | 2017-08-17 | 4 | GERAGHTY JAMES A | PIRS | Common Stock | D | 4,8200 | 10 000 | 48 | 10 000 | ||||
| 2017-08-11 | 2017-08-09 | 4 | Reine Allan | PIRS | Common Stock | D | 5,00 | 450 000 | 450 000 | |||||
| 2017-07-27 | 2017-07-25 | 4 | Richman Michael | PIRS | Stock Option (right to buy) | D | 5,64 | 3 288 | 3 288 | |||||
| 2017-07-27 | 2017-07-25 | 4 | Khuong Chau Quang | PIRS | Stock Option (right to buy) | D | 5,64 | 5 018 | 5 018 | |||||
| 2017-05-24 | 2017-05-22 | 4 | GERAGHTY JAMES A | PIRS | Stock Option (right to buy) | D | 3,94 | 30 000 | 30 000 | |||||
| 2017-05-09 | 2017-04-21 | 4 | KIRITSY CHRISTOPHER P | PIRS | Stock Option (right to buy) | D | 1,59 | -5 000 | 25 000 | |||||
| 2017-05-09 | 2017-04-21 | 4 | KIRITSY CHRISTOPHER P | PIRS | Common Stock | D | 1,5900 | 5 000 | 8 | 5 000 | ||||
| 2017-04-27 | 2017-04-25 | 4 | Richman Michael | PIRS | Stock Option (right to buy) | D | 2,32 | 7 821 | 7 821 | |||||
| 2017-04-27 | 2017-04-25 | 4 | Khuong Chau Quang | PIRS | Stock Option (right to buy) | D | 2,32 | 10 546 | 10 546 | |||||
| 2017-03-06 | 2017-02-23 | 4 | Matis Louis | PIRS | Stock option (Right to buy) | D | 1,99 | 145 000 | 145 000 | |||||
| 2017-03-06 | 2017-02-23 | 4 | Yoder Stephen S. | PIRS | Stock Option (Right to buy) | D | 1,99 | 434 350 | 434 350 | |||||
| 2017-01-30 | 2017-01-25 | 4 | Prelack Steven | PIRS | Stock Option (right to buy) | D | 2,01 | 20 000 | 20 000 | |||||
| 2017-01-30 | 2017-01-25 | 4 | Richman Michael | PIRS | Stock Option (right to buy) | D | 2,01 | 20 000 | 20 000 | |||||
| 2017-01-30 | 2017-01-25 | 4 | Richman Michael | PIRS | Stock Option (right to buy) | D | 2,01 | 9 687 | 9 687 | |||||
| 2017-01-30 | 2017-01-25 | 4 | ADAMS JULIAN | PIRS | Stock Option (right to buy) | D | 2,01 | 20 000 | 20 000 | |||||
| 2017-01-30 | 2017-01-25 | 4 | KIRITSY CHRISTOPHER P | PIRS | Stock Option (right to buy) | D | 2,01 | 20 000 | 20 000 | |||||
| 2017-01-30 | 2017-01-25 | 4 | Khuong Chau Quang | PIRS | Stock Option (right to buy) | D | 2,01 | 20 000 | 20 000 | |||||
| 2017-01-30 | 2017-01-25 | 4 | Khuong Chau Quang | PIRS | Stock Option (right to buy) | D | 2,01 | 10 313 | 10 313 | |||||
| 2017-01-30 | 2017-01-25 | 4 | BIZZARI JEAN-PIERRE | PIRS | Stock Option (right to buy) | D | 2,01 | 20 000 | 20 000 | |||||
| 2016-11-30 | 2016-11-28 | 4 | Knopf Claude | PIRS | Common Stock | D | 1,45 | 500 000 | 500 000 | |||||
| 2016-10-27 | 2016-10-25 | 4 | Richman Michael | PIRS | Stock Option (right to buy) | D | 1,64 | 9 656 | 9 656 | |||||
| 2016-10-27 | 2016-10-25 | 4 | Khuong Chau Quang | PIRS | Stock Option (right to buy) | D | 1,64 | 10 279 | 10 279 | |||||
| 2016-09-22 | 2016-09-20 | 4 | KIRITSY CHRISTOPHER P | PIRS | Stock Option (right to buy) | D | 1,59 | 30 000 | 30 000 | |||||
| 2016-08-01 | 2016-07-25 | 4 | Richman Michael | PIRS | Stock Option (right to buy) | D | 1,73 | 9 144 | 9 144 | |||||
| 2016-08-01 | 2016-07-25 | 4 | Khuong Chau Quang | PIRS | Stock Option (right to buy) | D | 1,73 | 9 734 | 9 734 | |||||
| 2016-07-26 | 2016-07-25 | 4 | ADAMS JULIAN | PIRS | Stock Option (right to buy) | D | 1,73 | 30 000 | 30 000 | |||||
| 2016-06-15 | 2016-06-13 | 4 | DEPTULA-HICKS DARLENE M | PIRS | Common Stock | D | 1,6600 | 5 000 | 8 | 5 000 | ||||
| 2016-06-15 | 2016-06-13 | 4 | Yoder Stephen S. | PIRS | Common Stock | D | 1,6800 | 6 000 | 10 | 6 000 | ||||
| 2016-06-15 | 2016-06-14 | 4 | Matis Louis | PIRS | Common Stock | D | 1,7100 | 7 915 | 14 | 10 000 | ||||
| 2016-06-15 | 2016-06-13 | 4 | Matis Louis | PIRS | Common Stock | D | 1,6800 | 2 085 | 4 | 2 085 | ||||
| 2016-04-29 | 2016-04-27 | 4 | Richman Michael | PIRS | Stock Option (right to buy) | D | 2,05 | 7 679 | 7 679 | |||||
| 2016-04-29 | 2016-04-27 | 4 | Khuong Chau Quang | PIRS | Stock Option (right to buy) | D | 2,05 | 8 174 | 8 174 | |||||
| 2016-02-18 | 2016-02-16 | 4 | Richman Michael | PIRS | Stock Option (right to buy) | D | 1,59 | 20 000 | 20 000 | |||||
| 2016-02-18 | 2016-02-16 | 4 | Prelack Steven | PIRS | Stock Option (right to buy) | D | 1,59 | 20 000 | 20 000 | |||||
| 2016-02-18 | 2016-02-16 | 4 | Khuong Chau Quang | PIRS | Stock Option (right to buy) | D | 1,59 | 20 000 | 20 000 | |||||
| 2016-02-18 | 2016-02-16 | 4 | BIZZARI JEAN-PIERRE | PIRS | Stock Option (right to buy) | D | 1,59 | 20 000 | 20 000 | |||||
| 2016-02-17 | 2016-02-12 | 4 | Yoder Stephen S. | PIRS | Stock Option (right to buy) | D | 1,52 | 492 000 | 492 000 | |||||
| 2016-01-20 | 2016-01-15 | 4 | Khuong Chau Quang | PIRS | Stock Option (right to buy) | D | 1,62 | 10 277 | 10 277 | |||||
| 2016-01-20 | 2016-01-15 | 4 | Richman Michael | PIRS | Stock Option (right to buy) | D | 1,62 | 9 654 | 9 654 | |||||
| 2015-10-30 | 2015-10-15 | 4 | Khuong Chau Quang | PIRS | Stock Option (right to buy) | D | 1,94 | 8 800 | 8 800 | |||||
| 2015-10-30 | 2015-10-15 | 4 | Richman Michael | PIRS | Stock Option (right to buy) | D | 1,94 | 8 267 | 8 267 | |||||
| 2015-09-03 | 2015-09-01 | 4 | DEPTULA-HICKS DARLENE M | PIRS | Common Stock | D | 2,80 | 450 000 | 450 000 | |||||
| 2015-08-18 | 2015-08-17 | 4 | Matis Louis | PIRS | Common Stock | D | 3,36 | 500 000 | 500 000 | |||||
| 2015-07-17 | 2015-07-15 | 4 | Khuong Chau Quang | PIRS | Stock Option (right to buy) | D | 2,55 | 6 717 | 6 717 | |||||
| 2015-07-17 | 2015-07-15 | 4 | Richman Michael | PIRS | Stock Option (right to buy) | D | 2,55 | 6 310 | 6 310 | |||||
| 2015-07-08 | 2015-07-06 | 4 | Khuong Chau Quang See Footnotes | PIRS | Common Stock | I | 2,7500 | 4 717 | 13 | 65 398 | ||||
| 2015-07-08 | 2015-07-06 | 4 | Khuong Chau Quang See Footnotes | PIRS | Common Stock | I | 2,7500 | 495 283 | 1 362 | 7 194 222 | ||||
| 2015-07-08 | 2015-07-06 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Common Stock | I | 2,7500 | 4 717 | 13 | 65 398 | ||||
| 2015-07-08 | 2015-07-06 | 4 | ORBIMED ADVISORS LLC See Footnotes | PIRS | Common Stock | I | 2,7500 | 495 283 | 1 362 | 7 194 222 | ||||
| 2015-06-29 | 3 | Khuong Chau Quang See Footnotes | PIRS | Common Stock | I | 13 458 559 | ||||||||
| 2015-06-29 | 3 | Khuong Chau Quang See Footnotes | PIRS | Common Stock | I | 6 820 301 | ||||||||
| 2015-06-29 | 3 | Khuong Chau Quang See Footnotes | PIRS | Common Stock | I | 13 458 559 | ||||||||
| 2015-06-29 | 3 | Khuong Chau Quang See Footnotes | PIRS | Common Stock | I | 6 820 301 | ||||||||
| 2015-06-29 | 3 | ISALY SAMUEL D See Footnotes | PIRS | Common Stock | I | 13 458 559 | ||||||||
| 2015-06-29 | 3 | ISALY SAMUEL D See Footnotes | PIRS | Common Stock | I | 13 458 559 | ||||||||
| 2015-06-29 | 3 | ISALY SAMUEL D See Footnotes | PIRS | Common Stock | I | 13 458 559 | ||||||||
| 2015-06-29 | 3 | ISALY SAMUEL D See Footnotes | PIRS | Common Stock | I | 6 820 301 | ||||||||
| 2015-06-29 | 3 | ISALY SAMUEL D See Footnotes | PIRS | Common Stock | I | 6 820 301 | ||||||||
| 2015-06-29 | 3 | ISALY SAMUEL D See Footnotes | PIRS | Common Stock | I | 13 458 559 | ||||||||
| 2015-06-29 | 3 | ISALY SAMUEL D See Footnotes | PIRS | Common Stock | I | 6 820 301 | ||||||||
| 2015-06-29 | 3 | ISALY SAMUEL D See Footnotes | PIRS | Common Stock | I | 6 820 301 |
P
Otwarty rynek lub prywatny zakup niepochodnych lub pochodnych papierów wartościowych
S
Otwarty rynek lub prywatna sprzedaż niepochodnych lub pochodnych papierów wartościowych
A
Grant, nagroda lub inne nabycie papierów wartościowych od spółki (np. opcja)
C
Konwersja instrumentu pochodnego
D
Sprzedaż lub przeniesienie papierów wartościowych z powrotem do spółki
F
Zapłata ceny wykonania lub zobowiązania podatkowego z wykorzystaniem części papierów wartościowych otrzymanych od spółki
G
Darowizna papierów wartościowych przez lub na rzecz insidera
K
Swapy kapitałowe i podobne transakcje zabezpieczające
M
Wykonanie lub konwersja pochodnego papieru wartościowego otrzymanego od spółki (takiego jak opcja)
V
Transakcja dobrowolnie zgłoszona na Formularzu 4
J
Inne (wraz z przypisem opisującym transakcję)
